ReviewInternational journal of environmental research and public health2013
The potential link between gut microbiota and IgE-mediated food allergy in early life.
Review in International journal of environmental research and public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Intestinal Microbiota in Early Life: Latest Findings Regarding the Role of Probiotics as a Treatment Approach for Dysbiosis.Nutrients · 2025Review
- Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders.Biomedicines · 2025Review
- The Association between Gut Microbiota and Serum Biomarkers in Children with Atopic Dermatitis.Biomedicines · 2024Article
- Bacteria and Allergic Diseases.International journal of molecular sciences · 2024Review
- Evolutive Study of Dietary Aspects and Intestinal Microbiota of Pediatric Cohort with Cow's Milk Protein Allergy.Children (Basel, Switzerland) · 2024Article
- Antimicrobial Stewardship: A Correct Management to Reduce Sepsis in NICU Settings.Antibiotics (Basel, Switzerland) · 2024Review
- Characteristics of the Gut Microbiota in Regard to Atopic Dermatitis and Food Allergies of Children.Biomedicines · 2024Article
- Intestinal permeability, food antigens and the microbiome: a multifaceted perspective.Frontiers in allergy · 2024Review
- Comparison of 16S rRNA gene sequencing microbiota among children with serological IgE-mediated food hypersensitivity.Pediatric research · 2024Article
- The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children.Nutrients · 2023Review
- Beyond allergic progression: From molecules to microbes as barrier modulators in the gut-lung axis functionality.Frontiers in allergy · 2023Review
- Cow's milk-induced gastrointestinal disorders: From infancy to adulthood.World journal of clinical pediatrics · 2022Article
- Review
- Acceptive Immunity: The Role of Fucosylated Glycans in Human Host-Microbiome Interactions.International journal of molecular sciences · 2021Review
- The Relationship Between Lower Respiratory Tract Microbiome and Allergic Respiratory Tract Diseases in Children.Frontiers in microbiology · 2021Article
- Transcriptional frameshifts contribute to protein allergenicity.The Journal of clinical investigation · 2020Article
- The Role of the Microbiome in Food Allergy: A Review.Children (Basel, Switzerland) · 2020Review
- A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment.Frontiers in immunology · 2020Review
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- The potential for pre-, pro- and synbiotics in the management of infants at risk of cow's milk allergy or with cow's milk allergy: An exploration of the rationale, available evidence and remaining questions.The World Allergy Organization journal · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been a dramatic rise in the prevalence of IgE-mediated food allergy over recent decades, particularly among infants and young children. The cause of this increase is unknown but one putative factor is a change in the composition, richness and balance of the microbiota that colonize the human gut during early infancy. The coevolution of the human gastrointestinal tract and commensal microbiota has resulted in a symbiotic relationship in which gut microbiota play a vital role in early life immune development and function, as well as maintenance of gut wall epithelial integrity. Since IgE mediated food allergy is associated with immune dysregulation and impaired gut epithelial integrity there is substantial interest in the potential link between gut microbiota and food allergy. Although the exact link between gut microbiota and food allergy is yet to be established in humans, recent experimental evidence suggests that specific patterns of gut microbiota colonization may influence the risk and manifestations of food allergy. An understanding of the relationship between gut microbiota and food allergy has the potential to inform both the prevention and treatment of food allergy. In this paper we review the theory and evidence linking gut microbiota and IgE-mediated food allergy in early life. We then consider the implications and challenges for future research, including the techniques of measuring and analyzing gut microbiota, and the types of studies required to advance knowledge in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.