ArticleToxins2013
A proteomics and transcriptomics investigation of the venom from the barychelid spider Trittame loki (brush-foot trapdoor).
Article in Toxins, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Synthesis of U-theraphotoxin-Pv1a_1, anToxicon: X · 2025Article
- Venomous Cargo: Diverse Toxin-Related Proteins Are Associated with Extracellular Vesicles in Parasitoid Wasp Venom.Pathogens (Basel, Switzerland) · 2025Article
- Identification and Evolutionary Analysis of the Widely Distributed CAP Superfamily in Spider Venom.Toxins · 2024Article
- A chromosome scale assembly of the parasitoid wasp Venturia canescens provides insight into the process of virus domestication.G3 (Bethesda, Md.) · 2023Article
- Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.).Scientific reports · 2022Article
- Molecular Diversity of Linear Peptides Revealed by Transcriptomic Analysis of the Venom Gland of the SpiderToxins · 2022Article
- Never, Ever Make an Enemy… Out of an Anemone: Transcriptomic Comparison of Clownfish Hosting Sea Anemone Venoms.Marine drugs · 2022Review
- Overview of protein posttranslational modifications in Arthropoda venoms.The journal of venomous animals and toxins including tropical diseases · 2022Review
- Characterization of the genome and silk-gland transcriptomes of Darwin's bark spider (Caerostris darwini).PloS one · 2022Article
- De Novo Transcriptome Analysis of the Venom ofMolecules (Basel, Switzerland) · 2021Article
- Article
- pH-Dependent Conformations of an Antimicrobial Spider Venom Peptide, Cupiennin 1a, from Unbiased HREMD Simulations.ACS omega · 2021Article
- Article
- Neuroactive venom compounds obtained fromThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Putative Antimicrobial Peptides of the Posterior Salivary Glands from the CephalopodAntibiotics (Basel, Switzerland) · 2020Article
- Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- An Economic Dilemma Between Molecular Weapon Systems May Explain an Arachno-atypical Venom in Wasp Spiders (Biomolecules · 2020Article
- Shifting evolutionary sands: transcriptome characterization of the Aptostichus atomarius species complex.BMC evolutionary biology · 2020Article
- Review
- Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses.Toxins · 2019Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as tarantulas), which last shared a most recent common ancestor with Barychelidae over 200 million years ago, has received much attention, accounting for 25% of all the described spider toxins while representing only 2% of all spider species. In this study, we evaluated for the first time the venom arsenal of a barychelid spider, Trittame loki, using transcriptomic, proteomic, and bioinformatic methods. The venom was revealed to be dominated by extremely diverse inhibitor cystine knot (ICK)/knottin peptides, accounting for 42 of the 46 full-length toxin precursors recovered in the transcriptomic sequencing. In addition to documenting differential rates of evolution adopted by different ICK/knottin toxin lineages, we discovered homologues with completely novel cysteine skeletal architecture. Moreover, acetylcholinesterase and neprilysin were revealed for the first time as part of the spider-venom arsenal and CAP (CRiSP/Allergen/PR-1) were identified for the first time in mygalomorph spider venoms. These results not only highlight the extent of venom diversification in this neglected ancient spider lineage, but also reinforce the idea that unique venomous lineages are rich pools of novel biomolecules that may have significant applied uses as therapeutics and/or insecticides.
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