ArticleArchives of disease in childhood2014
Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits.
Article in Archives of disease in childhood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Using urine nitrite sticks to test for urinary tract infection in children aged < 2 years: a meta-analysis.Pediatric nephrology (Berlin, Germany) · 2019Pooled it
- Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial.BMJ (Clinical research ed.) · 2017Trial
- Diagnostic accuracy of urine heparin binding protein for pediatric acute pyelonephritis.European journal of pediatrics · 2015Trial
- Urinary tract infection guidelines should address unique, specific questions and include analyses of primary data.Pediatric nephrology (Berlin, Germany) · 2024Article
- Rising resistance of urinary tract pathogens in children: a cause for concern.Irish journal of medical science · 2022Article
- Maternal antibiotic exposure during pregnancy is a risk factor for community-acquired urinary tract infection caused by extended-spectrum beta-lactamase-producing bacteria in infants.Pediatric nephrology (Berlin, Germany) · 2022Article
- A clinical prediction tool to predict urinary tract infection in pediatric febrile patients younger than 2 years old: a retrospective analysis of a fever registry.Clinical and experimental emergency medicine · 2021Article
- Long-term follow-up of premature infants with urinary tract infection.European journal of pediatrics · 2021Article
- Antibiotic resistance patterns of urinary tract pathogens in children from Central Romania.Experimental and therapeutic medicine · 2021Article
- Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade.Clinical and experimental pediatrics · 2021Article
- Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?Frontiers in pediatrics · 2021Review
- Impact of Antibiotic Prescribing Patterns on Susceptibilities of Uropathogens in Children below 24 Months Old.Antibiotics (Basel, Switzerland) · 2020Article
- A novel screening method for pediatric urinary tract infection using ordinary diapers.Scientific reports · 2020Article
- Collecting the golden water: Quality assessment on approach of diagnosing urinary tract infections in 0 to 36 months old children.Paediatrics & child health · 2020Article
- Defining urinary tract infection by bacterial colony counts: a case for 100,000 colonies/ml as the best threshold.Pediatric nephrology (Berlin, Germany) · 2019Article
- Utility of point-of-care Gram stain by physicians for urinary tract infection in children ≤36 months.Medicine · 2019Observational
- Prevalence and antimicrobial sensitivity pattern of urinary tract infection among children with cerebral palsy, Moshi, Tanzania.Pediatric health, medicine and therapeutics · 2018Article
- What Urinary Colony Count Indicates a Urinary Tract Infection in Children?The Journal of pediatrics · 2017Article
- Corticosteroids for renal scar prevention in children with acute pyelonephritis.Canadian family physician Medecin de famille canadien · 2017Review
- [Urinary tract infections in children].Der Urologe. Ausg. A · 2017Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test whether active management of urinary tract infections (UTI) in young children by general practitioners can reduce kidney scarring rates.
designA comparison of two audits in Newcastle, of children aged <8 years, presenting with UTIs ; a retrospective audit of conventional management during 1992-1995 (1990s) versus a prospective audit of direct access management during 2004-2011 (2000s).
main outcome measuresKidney scarring rates, and their relationship with time-to-treat.
resultsChildren with a first UTI in the 2000s compared to those in the 1990s, were referred younger, were half as likely to have a renal scar (girls OR 0.47, 95% CI 0.29 to 0.76; boys 0.35, 0.16 to 0.81), and were about 12 times more likely to have vesicoureteric reflux without scarring (girls 11.9, 4.3 to 33.5; boys 14.4, 4.3 to 47.6). In the 2000s, general practitioners treated about half the children at first consultation. Children who were treated within 3 days of their symptoms starting were one-third as likely to scar as those whose symptoms lasted longer (0.33, 0.12 to 0.72).
interpretationMost kidney defects seen in children after UTIs, are acquired scars, and in Newcastle, active management in primary care has halved this rate.
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