ArticleCancer biology & therapy2014
Alterations of high endothelial venules in primary and metastatic tumors are correlated with lymph node metastasis of oral and pharyngeal carcinoma.
Article in Cancer biology & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Targeting high endothelial venules: potential strategies for cancer treatment.Annals of medicine · 2025Review
- Lymphatic metastasis in pancreatic cancer: from bedside to bench and back.Cancer metastasis reviews · 2025Review
- Distinct maturity and spatial distribution of tertiary lymphoid structures in head and neck squamous cell carcinoma: implications for tumor immunity and clinical outcomes.Cancer immunology, immunotherapy : CII · 2025Article
- Computational methods for metastasis detection in lymph nodes and characterization of the metastasis-free lymph node microarchitecture: A systematic-narrative hybrid review.Journal of pathology informatics · 2024Review
- Targeting the tumour vasculature: from vessel destruction to promotion.Nature reviews. Cancer · 2024Review
- Automated detection of vascular remodeling in tumor-draining lymph nodes by the deep-learning tool HEV-finder.The Journal of pathology · 2022Article
- Role of tertiary lymphoid organs in the regulation of immune responses in the periphery.Cellular and molecular life sciences : CMLS · 2022Review
- High endothelial venules (HEVs) in immunity, inflammation and cancer.Angiogenesis · 2021Review
- The Dual Role of High Endothelial Venules in Cancer Progression versus Immunity.Trends in cancer · 2021Review
- High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer.Frontiers in immunology · 2021Review
- Insights Into Unveiling a Potential Role of Tertiary Lymphoid Structures in Metastasis.Frontiers in molecular biosciences · 2021Review
- CT-guidedTranslational oncology · 2017Article
- Biosynthesis and Functional Significance of Peripheral Node Addressin in Cancer-Associated TLO.Frontiers in immunology · 2016Review
- Histomolecular Structural Aspects of High Endothelial Vessels in Lymph Node and Its Significance in Oral Cancer and Metastasis.North American journal of medical sciences · 2015Review
- Increased expression of L-selectin (CD62L) in high-grade urothelial carcinoma: A potential marker for metastatic disease.Urologic oncology · 2015Article
- Article
- Alterations of high endothelial venules in primary and metastatic tumors are correlated with lymph node metastasis of oral and pharyngeal carcinoma.Cancer biology & therapy · 2014Article
- Impact of Early Diagnosis of Maxillofacial Metastases on Treatment and Patient Outcomes - A Retrospective Study.Annals of maxillofacial surgeryArticle
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9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High endothelial venules (HEVs) are special blood vessels in the paracortical region of lymph nodes (LNs) and govern lymphocyte recruitment. LN metastasis has similarity to circulating lymphocytes homing to LNs, but the role of HEVs in the progression of oral and pharyngeal squamous cell carcinoma (OPSCC) is unclear. In this study, we found that HEVs experienced a series of morphological and functional changes during OPSCC progression and were correlated with LN metastasis. In 9 cases of 73 metastatic LNs, tumor emboli were located adjacent to HEVs or just out of the vessels but not lymphatic channels. Gap junctions of tumor cells close to HEVs decreased or disappeared, and gaps were left at contact points where tumor cells attached to the HEVs. Moreover, the proliferation rate of endothelial cells of HEVs was the highest in metastatic LNs. Finally, L-selectin was detected in both primary and metastatic tumors, and it facilitated tumor cells adhering to LNs. In conclusion, our findings suggest that remodeled HEVs are correlated with LN metastasis of OPSCC and play important role in this process by preparing premetastatic soil for cancer cell metastasis.
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