ArticleEcology letters2014
Disentangling the interaction among host resources, the immune system and pathogens.
Article in Ecology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Host-pathogen interactions under pressure: A review and meta-analysis of stress-mediated effects on disease dynamics.Ecology letters · 2023Pooled it
- On the diverse and opposing effects of nutrition on pathogen virulence.Proceedings. Biological sciences · 2019Pooled it
- Playing it safe at early life stages: Balancing energy allocations to maximize fitness under seasonal pathogen dynamics.The Journal of animal ecology · 2026Article
- Insect immunity unveiled: exploring the molecular and cellular defenses against microbial threats.Archives of microbiology · 2026Review
- Bacterial killing assays in ecoimmunology require cross-validation by agreement statistics.Biology open · 2026Article
- An ecological model of vaginal dysbiosis provides new research leads.PLoS biology · 2026Article
- Swimming behavior of Daphnia dentifera is influenced by Australozyma monospora infection.PloS one · 2026Article
- Energetic shifts reflect survival likelihood in Anopheles gambiae.Communications biology · 2025Article
- Resources Modulate Developmental Shifts but Not Infection Tolerance Upon Co-Infection in an Insect System.Molecular ecology · 2025Article
- Population density drives increased parasitism via greater exposure and reduced resource availability in wild red deer.Parasitology · 2025Article
- On the Cause and Consequences of Coinfection: A General Mechanistic Framework of Within-Host Parasite Competition.Ecology letters · 2025Review
- Diet Driven Differences in Host Tolerance Are Linked to Shifts in Global Gene Expression in a Common Avian Host-Pathogen System.Molecular ecology · 2025Article
- A high-lipid diet leads to greater pathology and lower tolerance during infection.The Journal of experimental biology · 2025Article
- Diet of schistosome vectors influences infection outcomes.Ecosphere (Washington, D.C) · 2024Article
- Immunological feedback loops generate parasite persistence thresholds that explain variation in infection duration.Proceedings. Biological sciences · 2024Article
- Multispecies interactions and the community context of the evolution of virulence.Proceedings. Biological sciences · 2024Article
- Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection.Nature microbiology · 2024Article
- Resources modulate developmental shifts but not infection tolerance upon coinfection in an insect system.bioRxiv : the preprint server for biology · 2024Article
- Host resources and parasite traits interact to determine the optimal combination of host parasite-mitigation strategies.Ecology and evolution · 2024Article
- Effects of an entomopathogenic fungus on the reproductive potential ofEcology and evolution · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction between the immune system and pathogens is often characterised as a predator-prey interaction. This characterisation ignores the fact that both require host resources to reproduce. Here, we propose novel theory that considers how these resource requirements can modify the interaction between the immune system and pathogens. We derive a series of models to describe the energetic interaction between the immune system and pathogens, from fully independent resources to direct competition for the same resource. We show that increasing within-host resource supply has qualitatively distinct effects under these different scenarios. In particular, we show the conditions for which pathogen load is expected to increase, decrease or even peak at intermediate resource supply. We survey the empirical literature and find evidence for all three patterns. These patterns are not explained by previous theory, suggesting that competition for host resources can have a strong influence on the outcome of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.