Evidence map›Paper›PMID 24350715›Full record

ArticleJournal of cellular and molecular medicine2014

Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour?

Katarina Odar, Boštjan J Kocjan, Lea Hošnjak, Nina Gale, Mario Poljak, Nina Zidar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. "Histologic type, treatment and prognosis of carcinomas of the larynx: A review".Virchows Archiv : an international journal of pathology · 2026
    Review
  3. The histopathological spectrum of laryngeal epithelial neoplasia.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Development of head and neck pathology in Europe.Virchows Archiv : an international journal of pathology · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Observational
  16. How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017
    Review
  17. Article
  18. Morphologic diversity in human papillomavirus-related oropharyngeal squamous cell carcinoma: Catch Me If You Can!Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017
    Review
  19. Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katarina OdarFaculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia.
Boštjan J Kocjan
Lea Hošnjak
Nina Gale
Mario Poljak
Nina Zidar
University of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Association between verrucous carcinoma (VC) of the head and neck and human papillomaviruses (HPV) is highly controversial. Previous prevalence studies focused mostly on α-PV, while little is known about other PV genera. Our aim was to investigate the prevalence of a broad spectrum of HPV in VC of the head and neck using sensitive and specific molecular assays. Formalin-fixed, paraffin-embedded samples of 30 VC and 30 location-matched normal tissue samples were analysed, by using six different polymerase chain reaction-based methods targeting DNA of at least 87 HPV types from α-PV, β-PV, γ-PV and μ-PV genera, and immunohistochemistry against p16 protein. α-PV, γ-PV and μ-PV were not detected. β-PV DNA was detected in 5/30 VC (16.7%) and in 18/30 normal tissue samples (60.0%): HPV-19, -24 and -36 were identified in VC, and HPV-5, -9, -12, -23, -24, -38, -47, -49 and -96 in normal tissue, whereas HPV type was not determined in 2/5 cases of VC and in 6/18 normal tissue samples. p16 expression was detected in a subset of samples and was higher in VC than in normal tissue. However, the reaction was predominantly cytoplasmic and only occasionally nuclear, and the extent of staining did not exceed 75%. Our results indicate that α-PV, γ-PV and μ-PV are not associated with aetiopathogenesis of VC of the head and neck. β-PV DNA in a subset of VC and normal tissue might reflect incidental colonization, but its potential biological significance needs further investigation.

Indexed as

AdultAgedAged, 80 and overCarcinoma, VerrucousCyclin-Dependent Kinase Inhibitor p16DNA, ViralFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansIn Situ HybridizationMaleMiddle AgedNeoplasm ProteinsPapillomaviridaePapillomavirus InfectionsCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DNA, ViralNeoplasm Proteinshead and neckhuman papillomavirusesp16 proteinpolymerase chain reactionverrucous carcinoma

Identifiers

PMID24350715
PMCPMC4000115
OpenAlexW2013761593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.