ArticleThe Journal of organic chemistry2014
Biomimetic nitration of conjugated linoleic acid: formation and characterization of naturally occurring conjugated nitrodienes.
Article in The Journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Digestive interaction between dietary nitrite and dairy products generates novel nitrated linolenic acid products.Food chemistry · 2024Article
- Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONORedox biology · 2021Article
- Nitro-fatty acids as activators of hSIRT6 deacetylase activity.The Journal of biological chemistry · 2020Article
- Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells.Physiological genomics · 2019Article
- In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation.Redox biology · 2018Article
- Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid.Physiological genomics · 2018Article
- Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.Free radical biology & medicine · 2018Article
- Nitro-fatty acid pharmacokinetics in the adipose tissue compartment.Journal of lipid research · 2017Article
- The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid.The Journal of biological chemistry · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Nitro-conjugated linoleic acids (NO2-cLA), endogenous nitrodiene lipids which act as inflammatory signaling mediators, were isolated and single isomers purified from the biomimetic acidic nitration products of conjugated linoleic acid (CLA). Structures were elucidated by means of detailed NMR and HPLC-MS/MS spectroscopic analysis and the relative double bond configurations assigned. Additional synthetic methods produced useful quantities and similar isomeric distributions of these unusual and reactive compounds for biological studies and isotopic standards, and the potential conversion of nitro-linoleic to nitro-conjugated linoleic acids was explored via a facile base-catalyzed isomerization. This represents one of the few descriptions of naturally occurring conjugated nitro dienes (in particular, 1-nitro 1,3-diene), an unusual and highly reactive motif with few biological examples extant.
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Registered trials
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