Evidence map›Paper›PMID 24350259›Full record

ArticleBioMed research international2013

Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: the role of different gasotransmitters.

Vladimir Zivkovic, Vladimir Jakovljevic, Olga Pechanova, Ivan Srejovic, Jovana Joksimovic, Dragica Selakovic, Nevena Barudzic, Dragan M Djuric

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Vladimir ZivkovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Vladimir JakovljevicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Olga PechanovaInstitute of Normal and Pathological Physiology and Centre of Excellence for Examination of Regulatory Role of Nitric Oxide in Civilization Diseases, Slovak Academy of Sciences, Bratislava, Slovakia.
Ivan SrejovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Jovana JoksimovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Dragica SelakovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Nevena BarudzicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Dragan M DjuricInstitute of Medical Physiology "Richard Burian", Faculty of Medicine University of Belgrade, Belgrade, Serbia.
University of Kragujevac · RSInstitute of Normal and Pathological Physiology of the Slovak Academy of Sciences · SKUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the adverse effects of DL-homocysteine thiolactone hydrochloride (DL-Hcy TLHC) on vascular function and the possible role of oxidative stress in these mechanisms, the aim of this study was to assess the influence of DL-Hcy TLHC alone and in combination with specific inhibitors of important gasotransmitters, such as L-NAME, DL-PAG, and PPR IX, on cardiac contractility, coronary flow, and oxidative stress markers in an isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique at a 70 cm H2O and administered 10  μM DL-Hcy TLHC alone or in combination with 30  μM L-NAME, 10  μM DL-PAG, or 10  μM PPR IX. The following parameters were measured: dp/dt max, dp/dt min, SLVP, DLVP, MBP, HR, and CF. Oxidative stress markers were measured spectrophotometrically in coronary effluent through TBARS, NO2, O2(-), and H2O2 concentrations. The administration of DL-Hcy TLHC alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. DL-Hcy TLHC with L-NAME decreased CF, O2(-), H2O2, and TBARS. The administration of DL-Hcy TLHC with DL-PAG significantly increased dp/dt max but decreased DLVP, CF, and TBARS. Administration of DL-Hcy TLHC with PPR IX caused a decrease in dp/dt max, SLVP, HR, CF, and TBARS.

Indexed as

AnimalsBiomarkersCoronary CirculationGasotransmittersHeartHomocysteineHydrogen PeroxideMaleMuscle ContractionMyocardial ContractionMyocardiumOxidative StressRatsRats, WistarBiomarkersGasotransmittersHomocysteinehomocysteine thiolactoneHydrogen Peroxide

Identifiers

PMID24350259
PMCPMC3857920
OpenAlexW2070474058

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.