ReviewNephro-urology monthly2013
Overactive bladder syndrome and the potential role of prostaglandins and phosphodiesterases: an introduction.
Review in Nephro-urology monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function.Pharmacology research & perspectives · 2026Article
- Article
- Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome.World journal of urology · 2021Article
- International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin EPharmacological reviews · 2020Article
- Neuromodulation for functional bladder disorders in patients with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Review
- The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor.BMC urology · 2020Article
- Low amplitude rhythmic contraction frequency in human detrusor strips correlates with phasic intravesical pressure waves.World journal of urology · 2017Article
- Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3.Nature communications · 2015Article
- The cardiovascular and gastrointestinal adverse effects of cyclooxygenase inhibitors seems to be a major concern that restricts their use in the treatment of urinary bladder dysfunction.Central European journal of urology · 2015Article
- Effect of phosphodiesterase inhibitors in the bladder.Asian journal of urology · 2015Review
- Avanafil Inhibits the Contractility of the Isolated Caprine Detrusor Muscle.International journal of applied & basic medical researchArticle
- PATTERN OF OVERACTIVE BLADDER IN SOUTHEAST NIGERIA.Journal of the West African College of SurgeonsArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, a general introduction is given, presenting the overactive bladder syndrome (OAB) and its impact on the quality of life and economical burden in patients affected. Moreover, the anatomy, physiology and histology of the lower urinary tract are discussed, followed by a brief overview on the possible role of prostaglandin (PG) and phosphodiesterase type 5 (PDE5) in the urinary bladder. The current literature on the role and distribution of PGE2 and its receptors in the urinary bladder is discussed. In both animal models and in human studies, high levels of signaling molecules such as PG and cGMP have been implicated, in decreased functional bladder capacity and micturition volume, as well as in increased voiding contraction amplitude. As a consequence, inhibition of prostanoid production, the use of prostanoid receptor antagonists, or PDE inhibitors might be a rational way to treat patients with detrusor overactivity. Similarly, prostanoid receptor agonists, or agents that stimulate their production, might have a function in treating bladder underactivity.
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