ArticleFrontiers in cellular and infection microbiology2013
Aerosol-induced brucellosis increases TLR-2 expression and increased complexity in the microanatomy of astroglia in rhesus macaques.
Article in Frontiers in cellular and infection microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- A 3D Organotypic Human Bronchial Model Reveals Persistent Infection and Modulated Inflammatory Response when Exposed toTropical medicine and infectious disease · 2026Article
- Double trouble: The intersection of neurobrucellosis and systemic lupus erythematosus in a 24-year-old female.eNeurologicalSci · 2024Article
- Review
- Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis.The American journal of pathology · 2023Article
- Host immune responses in the central nervous system during fungal infections.Immunological reviews · 2022Review
- Live attenuated bacterium limits cancer resistance to CAR-T therapy by remodeling the tumor microenvironment.Journal for immunotherapy of cancer · 2022Article
- Phagocytosis by Peripheral Glia: Importance for Nervous System Functions and Implications in Injury and Disease.Frontiers in cell and developmental biology · 2021Review
- Glial Fibrillary Acidic Protein and Ionized Calcium-Binding Adapter Molecule 1 Immunostaining Score for the Central Nervous System of Horses With Non-suppurative Encephalitis and Encephalopathies.Frontiers in veterinary science · 2021Article
- Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases.Brain, behavior, and immunity · 2021Review
- A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Immunity Against Bacterial Infection of the Central Nervous System: An Astrocyte Perspective.Frontiers in molecular neuroscience · 2019Review
- Spinal Interleukin-1β Inhibits Astrocyte Cytochrome P450c17 Expression Which Controls the Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.Frontiers in molecular neuroscience · 2019Article
- Culture Model for Non-human Primate Choroid Plexus.Frontiers in cellular neuroscience · 2019Article
- Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.Journal of intellectual disability research : JIDR · 2018Article
- Mucosal bacterial dissemination in a rhesus macaque model of experimental brucellosis.Journal of medical primatology · 2018Article
- Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain.Scientific reports · 2017Article
- The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection.Seminars in immunopathology · 2017Review
- The flavivirus dengue induces hypertrophy of white matter astrocytes.Journal of neurovirology · 2016Article
- Glial cell morphological and density changes through the lifespan of rhesus macaques.Brain, behavior, and immunity · 2016Article
- Neuropathogenesis of Chikungunya infection: astrogliosis and innate immune activation.Journal of neurovirology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Brucella melitensis, a bacterial pathogen and agent of epizootic abortion causes multiple pathologies in humans as well as a number of agriculturally important animal species. Clinical human brucellosis manifests as a non-specific, chronic debilitating disease characterized by undulant fever, arthropathies, cardiomyopathies and neurological sequelae. These symptoms can occur acutely for a few weeks or persist for months to years. Within the brain, endothelial and glial cells can be infected leading to downstream activation events including matrix metalloprotease (MMP) and cytokine secretion and Toll-like receptor (TLR) signaling. These events are likely to lead to tissue remodeling, including morphologic changes in neuronal and glial cells, which are linked to neurological complications including depressive behavior, immune activation and memory loss. Our hypothesis was that B. melitensis infection and neurobrucellosis would lead to activation of astrocytes through upregulation of TLR2 and stimulate concurrent changes in the microanatomy. All six animals were infected via inhalation route. TLR2 expression was approximately doubled in white matter astrocytes of infected rhesus macaques. There was also a 50% increase in the number of astrocytes per unit area in subcortical white matter tracts suggesting increased innate immune activation. This coincided with dramatic increases in the length and complexity of the cell arbor of hypertrophic astrocytes in both cortical gray and white matter. Thus, aerosol-induced brucellosis results in dramatically increased innate immune activation of astrocytes in the absence of widespread neuroinflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.