ArticleJournal of advanced pharmaceutical technology & research2013
Effect of formulation factors on in vitro transcorneal permeation of voriconazole from aqueous drops.
Article in Journal of advanced pharmaceutical technology & research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Characterization of Liquid Formulations for Enhanced Buccal Permeation: Exploring Key Attributes.Biomedicines · 2026Article
- Terconazole loaded edge-activated hybrid elastosome for revamped corneal permeation in ocular mycosis: In-vitro characterization, statistical optimization, microbiological assessment, and in-vivo evaluation.International journal of pharmaceutics: X · 2025Article
- Exploring the potential of antifungal-loaded proniosomes to consolidate corneal permeation in fungal keratitis: A comprehensive investigation from laboratory characterization to microbiological evaluation.International journal of pharmaceutics: X · 2025Article
- Expanding Arsenal against Ocular Diseases through Nanoemulsion: Success So Far and the Road Ahead.Current drug delivery · 2025Review
- Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease.Beilstein journal of nanotechnology · 2025Article
- A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration.Drug delivery · 2023Review
- Chitosan-Coated SLN: A Potential System for Ocular Delivery of Metronidazole.Pharmaceutics · 2023Article
- Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management.Drug delivery · 2022Article
- Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation,Drug delivery · 2022Article
- Development and Characterization of Nanoemulsions for Ophthalmic Applications: Role of Cationic Surfactants.Materials (Basel, Switzerland) · 2021Review
- Ophthalmic Nanoemulsions: From Composition to Technological Processes and Quality Control.Molecular pharmaceutics · 2021Review
- Current perspectives on corneal collagen crosslinking (CXL).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Review
- Topical delivery of acetazolamide by encapsulating in mucoadhesive nanoparticles.Asian journal of pharmaceutical sciences · 2017Article
- Influence of freeze-drying and γ-irradiation in preclinical studies of flurbiprofen polymeric nanoparticles for ocular delivery using d-(+)-trehalose and polyethylene glycol.International journal of nanomedicineArticle
- Effect of Smartphone Light Fluxes on Cornea: A Biophysical Study.Journal of medical physicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this research was to evaluate the effect the formulation factors on in vitro permeation of voriconazole through freshly isolated goat and sheep corneas. An increase in the pH of the drops from 4.0 to 8.0 resulted in significant (P < 0.05) increase drug permeation. Raising concentration of the drops from 0.05% to 0.2% (w/v) significantly, (P < 0.05) increased drug permeation, but decreased the percent permeation. Corneal transport of voriconazole is both pH and concentration dependent. Eye drops containing disodium edetate (ethylenediaminetetraacetic acid) alone or combination with benzalkonium chloride showed significantly (P < 0.05) higher permeation as compared with control formulation. Addition of beta-cyclodextrin to the formulation enhanced corneal permeation of voriconazole. Compared with control formulation, voriconazole 0.2% (w/v) drop containing viscosity modifier produced significant (P < 0.05) decrease in permeation. Most of the formulations showed higher zone of inhibition against Candida albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.