Evidence map›Paper›PMID 24349805›Full record

ArticleCase reports in hematology2013

Biclonal IgD and IgM Plasma Cell Myeloma: A Report of Two Cases and a Literature Review.

Zhongchuan W Chen, Ioanna Kotsikogianni, Jay S Raval, Christine G Roth, Marian A Rollins-Raval

Open access · goldAbstract read
In one paragraph

Article in Case reports in hematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. An interesting case of renal amyloidosis.Indian journal of nephrology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Zhongchuan W ChenDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A1.
Ioanna KotsikogianniPathology Laboratory, Patras General Hospital "O Agios Andreas," 26500 Patras, Greece.
Jay S RavalDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA ; The Institute for Transfusion Medicine, Pittsburgh, PA 15213, USA ; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.
Christine G RothDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Marian A Rollins-RavalDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA ; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525, USA.
University of Pittsburgh · USAgios Andreas Hospital · GRInstitute for Transfusion Medicine · USUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biclonal plasma cell myelomas producing two different isotypes of immunoglobulins are extremely rare entities; to date, the combination of IgD and IgM secretion by a biclonal plasma cell myeloma has not been reported. Bone marrow biopsy immunohistochemical studies in two cases revealed neoplastic plasma cells coexpressing IgD and IgM, but serum protein electrophoresis identified only the IgM monoclonal paraprotein in both cases. Biclonal plasma cell myelomas, while currently not well characterized in terms of their clinical behavior, should be distinguished from B-cell lymphoma with plasmacytic differentiation, given the different therapeutic implications. Both cases reported herein demonstrated chemotherapy-resistant clinical courses.

Identifiers

PMID24349805
PMCPMC3855939
OpenAlexW2045638842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.