ArticleIranian Red Crescent medical journal2013
Genetic Analysis of cagA and vacA Genes in Helicobacter Pylori Isolates and Their Relationship with Gastroduodenal Diseases in the West of Iran.
Article in Iranian Red Crescent medical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.BMC gastroenterology · 2026Article
- Recent advances in rapid detection of Helicobacter pylori by lateral flow assay.Archives of microbiology · 2025Review
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- Use of immunoinformatics and the simulation approach to identify Helicobacter pylori epitopes to design a multi-epitope subunit vaccine for B- and T-cells.BMC biotechnology · 2023Article
- Helicobacter pylori strains isolated from raw poultry meat: frequency and molecular characteristics.Scientific reports · 2023Article
- Is There a Real Relationship between the Presence ofInternational journal of microbiology · 2023Article
- The association between metabolic syndrome and erosive esophagitis: A systematic review and meta-analysis.EXCLI journal · 2021Review
- Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020Review
- Detection of Helicobacter pylori and its virulence genes (cagA, dupA, and vacA) among patients with gastroduodenal diseases in Chris Hani Baragwanath Academic Hospital, South Africa.BMC gastroenterology · 2019Article
- Analysis ofGastroenterology research · 2018Article
- Prevalence ofInternational journal of microbiology · 2018Article
- Phenotypic analysis of antibiotic resistance and genotypic study of theAntimicrobial resistance and infection control · 2018Article
- Genotyping and antibiotic resistance properties ofInfection and drug resistance · 2018Article
- High Frequency of vacA s1m2 Genotypes Among Helicobacter pylori Isolates From Patients With Gastroduodenal Disorders in Kermanshah, Iran.Jundishapur journal of microbiology · 2015Article
- Milk of livestock as a possible transmission route of Helicobacter pylori infection.Gastroenterology and hepatology from bed to bench · 2015Article
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5 authors.
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Abstract
backgroundHelicobacter pylori have different virulence factors which are associated with several gastroduodenal diseases; however, this association is variable in different geographical regions. Data of genotypes of Iranian H. pylori isolates are few.
objectivesThe aim of the current study was to investigate the cagA/vacA genotypes of Helicobacter pylori isolates and determine the relationship between these genotypes with respect to different gastric disorders in patients of Chaharmahalo Bakhtiarian. MATERIALS AND
methodsIn this cross-sectional study, gastric biopsies were taken from 200 patients with gastrodoudenal diseases. Histopathological features were recognized by specialist. The samples were subjected to PCR for detection and identification of ureC, cagA and vacA genes.
resultsThe frequency of the vacA genotypes, sa1/m1, s1a/m1b, s1a/m2, s1b/m1a, s1b/m1b, s1b/m2, s1c/m1a, s1c/m1b, s1c/m2, s2/m1a, s2/m1b and s2/m2 were 27(6.6%), 8(4.3%), 45(28.04%), 7(3.7%), 5(2.5%), 10 (6.1%), 12 (7.4%), 4 (2.5%), 18(11%), 6(3.7%), 0 and 22(13.5%) respectively. The cagA gene was detected in 92% of strains. Based on our findings, it seemed that cagPAI and vacA s1 genotypes were associated with some gastric disorders in patients with H. pylori. In this region, the isolates carrying s1a/m2 were the most prevalent.
conclusionsWe found considerable relationship between s1a/m1a, s1a/m2, s2/m2 and s1c/m1a and some gastric disorders. Further studies about the role of H. pylori virulence factors and gastric disorders were recommended.
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