ReviewOxidative medicine and cellular longevity2013
Protective role of melatonin in neonatal diseases.
Review in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Melatonin for pre-medication in children: a systematic review.BMC pediatrics · 2022Pooled it
- Efficacy of Liposomal Melatonin in sleep EEG in Childhood: A Double Blind Case Control Study.International journal of environmental research and public health · 2022Trial
- Review
- [Advances in pharmacological research for retinopathy of prematurity].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Melatonin, an Antitumor Necrosis Factor Therapy.Journal of pineal research · 2025Review
- Efficacy of melatonin in alleviating disorders arising from repeated exposure to sevoflurane in males and females of the Wistar rats during preadolescence.Scientific reports · 2024Article
- The effect of phototherapy treatment on serum melatonin levels in term newborns.Turkish journal of medical sciences · 2024Observational
- MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia.Journal of molecular neuroscience : MN · 2023Article
- The relationship of melatonin concentration in preterm infants and adverse outcomes in the late neonatal period.Biochemia medica · 2023Article
- Chorioamnionitis disrupts erythropoietin and melatonin homeostasis through the placental-fetal-brain axis during critical developmental periods.Frontiers in physiology · 2023Article
- The Multiple Functions of Melatonin: Applications in the Military Setting.Biomedicines · 2022Review
- The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn.Biomedicines · 2022Review
- Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders.International journal of molecular sciences · 2021Review
- Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds.Molecules (Basel, Switzerland) · 2021Review
- Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.Biomolecules · 2021Review
- Coronaviruses in children: A review of potential mechanisms of childhood protection.Acta paediatrica (Oslo, Norway : 1992) · 2021Review
- Use of Melatonin in Oxidative Stress Related Neonatal Diseases.Antioxidants (Basel, Switzerland) · 2020Review
- Immunometabolic approaches to prevent, detect, and treat neonatal sepsis.Pediatric research · 2020Review
- Perinatal Use of Melatonin for Offspring Health: Focus on Cardiovascular and Neurological Diseases.International journal of molecular sciences · 2019Review
- Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care.Cell death & disease · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress contributes to the severity of several newborn conditions to the extent that Saugstad coined the phrase "oxygen radical diseases of neonatology." In order to counteract free radicals damage many strategies to augment antioxidant status in ill-term and preterm infants have been proposed and several medications have been experimented with mixed results. Several studies have tested the efficacy of melatonin to counteract oxidative damage in diseases of newborns such as chronic lung disease, perinatal brain injury, necrotizing enterocolitis, and retinopathy of prematurity, giving promising results. The peculiar perinatal susceptibility to oxidative stress indicates that prophylactic use of antioxidants as melatonin could help to prevent or at least reduce oxidative stress related diseases in newborns. However, more studies are needed to confirm these beneficial effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.