ArticleOxidative medicine and cellular longevity2013
Tetrahydroxystilbene glucoside attenuates neuroinflammation through the inhibition of microglia activation.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Metal-Associated Particulate Matter (PMInternational journal of molecular sciences · 2025Article
- A review: oxidative stress in skeletal muscle and the non-coding RNAs behind it.Molecular and cellular biochemistry · 2025Review
- Preclinical Evidence and Underlying Mechanisms ofJournal of pharmacopuncture · 2024Review
- 2,3,5,4'-Tetrahydroxystilbene-2-Frontiers in cell and developmental biology · 2022Article
- A Review of Pharmacology, Toxicity and Pharmacokinetics of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside.Frontiers in pharmacology · 2021Review
- Herb-Induced Liver Injury Related toFrontiers in pharmacology · 2021Review
- Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways.BMC complementary medicine and therapies · 2020Article
- Tetrahydroxystilbene Glucoside Ameliorates Infrasound-Induced Central Nervous System (CNS) Injury by Improving Antioxidant and Anti-Inflammatory Capacity.Oxidative medicine and cellular longevity · 2020Article
- Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Current Drugs and Potential Future Neuroprotective Compounds for Parkinson's Disease.Current neuropharmacology · 2019Review
- Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Dual modulation on glial cells by tetrahydroxystilbene glucoside protects against dopamine neuronal loss.Journal of neuroinflammation · 2018Article
- Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted fromOxidative medicine and cellular longevity · 2018Review
- Tetrahydroxystilbene Glucoside Produces Neuroprotection against 6-OHDA-Induced Dopamine Neurotoxicity.Oxidative medicine and cellular longevity · 2018Article
- 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.Scientific reports · 2017Article
- 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside protects murine hearts against ischemia/reperfusion injury by activating Notch1/Hes1 signaling and attenuating endoplasmic reticulum stress.Acta pharmacologica Sinica · 2017Article
- 2,3,5,4'-Tetrahydroxystilbene-2-O-Oxidative medicine and cellular longevity · 2016Article
- Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments.Oxidative medicine and cellular longevity · 2016Review
- Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB and ERK signaling pathways in BV2 cells.PloS one · 2014Article
- Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke.BioMed research international · 2014Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation is closely implicated in the pathogenesis of neurological diseases. The hallmark of neuroinflammation is the microglia activation. Upon activation, microglia are capable of producing various proinflammatory factors and the accumulation of these factors contribute to the neuronal damage. Therefore, inhibition of microglia-mediated neuroinflammation might hold potential therapy for neurological disorders. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component extracted from Polygonum multiflorum, is reported to be beneficial for human health with a great number of pharmacological properties including antioxidant, free radical-scavenging, anti-inflammation, antilipemia, and cardioprotective effects. Recently, TSG-mediated neuroprotective effects have been well demonstrated. However, the neuroprotective actions of TSG on microglia-induced neuroinflammation are not known. In the present study, microglia BV2 cell lines were applied to investigate the anti-neuroinflammatory effects of TSG. Results showed that TSG reduced LPS-induced microglia-derived release of proinflammatory factors such as TNFα, IL-1β, and NO. Moreover, TSG attenuated LPS-induced NADPH oxidase activation and subsequent reactive oxygen species (ROS) production. Further studies indicated that TSG inhibited LPS-induced NF-κB signaling pathway activation. Together, TSG exerted neuroprotection against microglia-mediated neuroinflammation, suggesting that TSG might present a promising benefit for neurological disorders treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.