ReviewOxidative medicine and cellular longevity2013
Accelerated aging in major depression: the role of nitro-oxidative stress.
Review in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024.Frontiers in neuroscience · 2025Article
- The Dual Role of Amyloid Beta-Peptide in Oxidative Stress and Inflammation: Unveiling Their Connections in Alzheimer's Disease Etiopathology.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota.Antioxidants (Basel, Switzerland) · 2022Review
- Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders.International journal of molecular sciences · 2022Review
- Associations Between DNA Methylation Age Acceleration, Depressive Symptoms, and Cardiometabolic Traits in African American Mothers From the InterGEN Study.Epigenetics insights · 2022Article
- Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults.Journal of affective disorders · 2019Article
- Gut Microbiota in Alzheimer's Disease, Depression, and Type 2 Diabetes Mellitus: The Role of Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- Oxidative Stress-Related Endothelial Damage in Vascular Depression and Vascular Cognitive Impairment: Beneficial Effects of Aerobic Physical Exercise.Oxidative medicine and cellular longevity · 2019Review
- Molecular Bases of Alzheimer's Disease and Neurodegeneration: The Role of Neuroglia.Aging and disease · 2018Review
- Oxidative stress, inflammation and treatment response in major depression.Psychoneuroendocrinology · 2017Article
- Is there Progress? An Overview of Selecting Biomarker Candidates for Major Depressive Disorder.Frontiers in psychiatry · 2016Review
- Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging.Neuroscience and biobehavioral reviews · 2015Review
- A mitochondrial bioenergetic basis of depression.Journal of bioenergetics and biomembranes · 2015Review
- Effects of long-term sertraline treatment and depression on coronary artery atherosclerosis in premenopausal female primates.Psychosomatic medicine · 2015Article
- Dietary Antioxidant and Flavonoid Intakes Are Reduced in the Elderly.Oxidative medicine and cellular longevity · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitro-oxidative stress (NOS) plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative disorders, and major depression (MD). The latter is a very frequent psychiatric illness characterized by accelerated aging, neurodegeneration, high comorbidity with age-related disorders, and premature mortality; all of these conditions find an explanation in an altered redox homeostasis. If aging, neurodegeneration, and major depression share a common biological base in their pathophysiology, common therapeutic tools could be investigated for the prevention and treatment of these disorders. As an example, antidepressants have been demonstrated to present neuroprotective and anti-inflammatory properties and to stimulate neurogenesis. In parallel, antioxidants that stimulate the antioxidant defense systems and interact with the monoaminergic system show an antidepressant-like activity. Further research on this topic could lead, in the near future, to the expansion of the therapeutic possibilities for the treatment of NOS-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.