ArticleCommunicative & integrative biology2013
The role of the actin cortex in maintaining cell shape.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Non-erythrocyte spectrin network preferentially stabilizes flat membrane and enhances cell stiffness.RSC advances · 2025Article
- Epithelial cell shape changes contribute to regulation of ureteric bud branching morphogenesis.The FEBS journal · 2025Article
- Mechanical properties of human tumour tissues and their implications for cancer development.Nature reviews. Physics · 2024Article
- Review
- Adherent Bacteria and Parasiticidal Secretion Products of Human Cervicovaginal Microbiota-AssociatedPharmaceuticals (Basel, Switzerland) · 2022Article
- Nucleation causes an actin network to fragment into multiple high-density domains.Biophysical journal · 2022Article
- Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Role of Cytoskeleton Revealed by Quartz Crystal Microbalance and Digital Holographic Microscopy.International journal of molecular sciences · 2022Article
- Review
- Nonlinear Actin Deformations Lead to Network Stiffening, Yielding, and Nonuniform Stress Propagation.Biophysical journal · 2017Article
- Antagonistic Behaviors of NMY-1 and NMY-2 Maintain Ring Channels in the C. elegans Gonad.Biophysical journal · 2016Article
- Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration.Journal of biomechanics · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considering that the plasma membrane is host to a variety of mechanical cues in vivo, and the actin cortex is known to support cell shape, it comes as no surprise that the paired membrane-cortex plays a major role in cellular responses to deformation. In a recent study, we applied highly localized forces to HeLa cells in order to examine the deformation response of the membrane and cortex. Direct visualization of the deformation in the loading plane allowed for the characterization of the observed time-dependent strain. Despite large magnitude and long duration loading regimes, the majority of cells recovered their initial pre-deformed morphology within ~2 min. Unexpectedly, perturbed regions above large-volume nuclei were shown to be quite soft and had negligible influence on morphological recovery. The resistance to deformation and ability to recover was found to be largely influenced by the actin network, and dependent upon rho-kinase mediated contractility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.