Trial reportPloS one2013
BOLD Granger causality reflects vascular anatomy.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.Journal of anxiety disorders · 2023Pooled it
- Multivariate analysis of correlation between electrophysiological and hemodynamic responses during cognitive processing.NeuroImage · 2014Trial
- Systemic physiological "noise" in fMRI has clinical relevance.medRxiv : the preprint server for health sciences · 2025Article
- Forecasting brain activity based on models of spatiotemporal brain dynamics: A comparison of graph neural network architectures.Network neuroscience (Cambridge, Mass.) · 2022Article
- Causal mapping of human brain function.Nature reviews. Neuroscience · 2022Review
- The Structured Mind at Rest: Low-Frequency Oscillations Reflect Interactive Dynamics Between Spontaneous Brain Activity and a Common Architecture for Task Control.Frontiers in neuroscience · 2022Article
- Alteration of Effective Connectivity in the Default Mode Network of Autism After an Intervention.Frontiers in neuroscience · 2021Article
- Temporal embedding and spatiotemporal feature selection boost multi-voxel pattern analysis decoding accuracy.Journal of neuroscience methods · 2020Article
- Preservation Effect: Cigarette Smoking Acts on the Dynamic of Influences Among Unifying Neuropsychiatric Triple Networks in Schizophrenia.Schizophrenia bulletin · 2019Article
- Article
- fMRI in Non-human Primate: A Review on Factors That Can Affect Interpretation and Dynamic Causal Modeling Application.Frontiers in neuroscience · 2019Review
- Article
- Disentangling causal webs in the brain using functional magnetic resonance imaging: A review of current approaches.Network neuroscience (Cambridge, Mass.) · 2019Review
- Psychosocial stress reactivity is associated with decreased whole-brain network efficiency and increased amygdala centrality.Behavioral neuroscience · 2018Article
- Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory.Human brain mapping · 2018Article
- Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.JAMA network open · 2018Article
- The Hierarchical Organization of the Default, Dorsal Attention and Salience Networks in Adolescents and Young Adults.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- The Hippocampus and Amygdala Are Integrators of Neocortical Influence: A CorticoCortical Evoked Potential Study.Brain connectivity · 2017Article
- Top-down cortical interactions in visuospatial attention.Brain structure & function · 2017Article
- Magnetic resonance advection imaging of cerebrovascular pulse dynamics.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A number of studies have tried to exploit subtle phase differences in BOLD time series to resolve the order of sequential activation of brain regions, or more generally the ability of signal in one region to predict subsequent signal in another region. More recently, such lag-based measures have been applied to investigate directed functional connectivity, although this application has been controversial. We attempted to use large publicly available datasets (FCON 1000, ADHD 200, Human Connectome Project) to determine whether consistent spatial patterns of Granger Causality are observed in typical fMRI data. For BOLD datasets from 1,240 typically developing subjects ages 7-40, we measured Granger causality between time series for every pair of 7,266 spherical ROIs covering the gray matter and 264 seed ROIs at hubs of the brain's functional network architecture. Granger causality estimates were strongly reproducible for connections in a test and replication sample (n=620 subjects for each group), as well as in data from a single subject scanned repeatedly, both during resting and passive video viewing. The same effect was even stronger in high temporal resolution fMRI data from the Human Connectome Project, and was observed independently in data collected during performance of 7 task paradigms. The spatial distribution of Granger causality reflected vascular anatomy with a progression from Granger causality sources, in Circle of Willis arterial inflow distributions, to sinks, near large venous vascular structures such as dural venous sinuses and at the periphery of the brain. Attempts to resolve BOLD phase differences with Granger causality should consider the possibility of reproducible vascular confounds, a problem that is independent of the known regional variability of the hemodynamic response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.