ArticlePloS one2013
Histopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- EnhancedInfection and immunity · 2026Article
- Research progress on immunoprotective mechanisms of enteric fever and vaccine development.Journal of advanced research · 2026Review
- A new mouse model of typhoid fever usingmBio · 2026Article
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- Bacterial Infections and Cancer: Exploring This Association And Its Implications for Cancer Patients.International journal of molecular sciences · 2023Review
- Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection.Infection and immunity · 2022Article
- Association of Microbial Dysbiosis with Gallbladder Diseases Identified by Bile Microbiome Profiling.Journal of Korean medical science · 2021Article
- Article
- Pathoadaptive Alteration ofJournal of bacteriology · 2019Article
- Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models.Frontiers in immunology · 2019Review
- Terminal Deoxynucleotidyl Transferase Is Not Required for Antibody Response to Polysaccharide Vaccines against Streptococcus pneumoniae and Salmonella enterica Serovar Typhi.Infection and immunity · 2018Article
- An Unmutated IgM Response to the Vi Polysaccharide ofJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Presence ofOncotarget · 2017Article
- Effect of Various Inoculum Levels of Multidrug-ResistantFrontiers in microbiology · 2017Article
- Bile Acids Function Synergistically To Repress Invasion Gene Expression in Salmonella by Destabilizing the Invasion Regulator HilD.Infection and immunity · 2016Article
- Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.Science (New York, N.Y.) · 2015Article
- The deadly bite of Salmonella Typhi.EMBO reports · 2015Article
- Salmonella chronic carriage: epidemiology, diagnosis, and gallbladder persistence.Trends in microbiology · 2014Review
- The conspiracy of autophagy, stress and inflammation in acute pancreatitis.Current opinion in gastroenterology · 2014Review
- Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ.Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Salmonella Typhi asymptomatic chronic carriage represents a challenge for the diagnosis and prevention of typhoid fever in endemic areas. Such carriers are thought to be reservoirs for further spread of the disease. Gallbladder carriage has been demonstrated to be mediated by biofilm formation on gallstones and by intracellular persistence in the gallbladder epithelium of mice. In addition, both gallstones and chronic carriage have been associated with chronic inflammation and the development of gallbladder carcinoma. However, the pathogenic relationship between typhoid carriage and the development of pre-malignant and/or malignant lesions in the hepatopancreatobiliary system as well as the host-pathogen interactions occurring during chronic carriage remains unclear. In this study, we monitored the histopathological features of chronic carriage up to 1 year post-infection. Chronic cholecystitis and hepatitis ranging from mild to severe were present in infected mice regardless of the presence of gallstones. Biliary epithelial hyperplasia was observed more commonly in the gallbladder of mice with gallstones (uninfected or infected). However, pre-malignant lesions, atypical hyperplasia and metaplasia of the gallbladder and exocrine pancreas, respectively, were only associated with chronic Salmonella carriage. This study has implications regarding the role of Salmonella chronic infection and inflammation in the development of pre-malignant lesions in the epithelium of the gallbladder and pancreas that could lead to oncogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.