ArticlePloS one2013
Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies.International journal of molecular sciences · 2021Pooled it
- Mechanobiology of Matricellular Proteins in Bladder Cancer: A Narrative Review and Bioinformatics Analysis.Biomolecules · 2026Review
- Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity.The Journal of clinical endocrinology and metabolism · 2026Article
- The Effect of Resistance Training and Ursolic Acid on the PI3K-AKT-mTOR Pathway in Aged Diabetic Rats: A Comparative Study.Aging medicine (Milton (N.S.W)) · 2026Article
- Periostin as a diagnostic marker and therapeutic target for intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2025Article
- Periodontal ligament stem cells in tissue remodeling: from mechanical forces to inflammatory signals.Stem cell research & therapy · 2025Review
- Integration of Melt Electrowritten Polymeric Scaffolds and Bioprinting for Epithelial Healing via Localized Periostin Delivery.ACS macro letters · 2024Article
- Feeling the Heat. Mapping the Epigenetic Modifications of Histone during Burn Wound Healing.Journal of burn care & research : official publication of the American Burn Association · 2024Article
- The role of periostin in cardiac fibrosis.Heart failure reviews · 2024Review
- Mechanisms of tissue degeneration mediated by periostin in spinal degenerative diseases and their implications for pathology and diagnosis: a review.Frontiers in medicine · 2023Review
- Agonist (P1) Antibody Converts Stem Cells into Migrating Beta-Like Cells in Pancreatic Islets.Journal of microbiology and biotechnology · 2022Article
- mTOR Signaling Components in Tumor Mechanobiology.International journal of molecular sciences · 2022Review
- Review
- Treadmill exercise influences the microRNA profiles in the bone tissues of mice.Experimental and therapeutic medicine · 2021Article
- Expression of Musashi-1 Increases in Bone Healing.International journal of molecular sciences · 2021Article
- Interleukin-1β Induced Matrix Metalloproteinase Expression in Human Periodontal Ligament-Derived Mesenchymal Stromal Cells under In Vitro Simulated Static Orthodontic Forces.International journal of molecular sciences · 2021Article
- Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases.Frontiers in medicine · 2021Review
- Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study.Respiratory research · 2020Observational
- Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.Cell reports · 2020Article
- Topical delivery of mTOR inhibitor halts scarring.Journal of dermatological science · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Current knowledge about Periostin biology has expanded from its recognized functions in embryogenesis and bone metabolism to its roles in tissue repair and remodeling and its clinical implications in cancer. Emerging evidence suggests that Periostin plays a critical role in the mechanism of wound healing; however, the paracrine effect of Periostin in epithelial cell biology is still poorly understood. We found that epithelial cells are capable of producing endogenous Periostin that, unlike mesenchymal cell, cannot be secreted. Epithelial cells responded to Periostin paracrine stimuli by enhancing cellular migration and proliferation and by activating the mTOR signaling pathway. Interestingly, biomechanical stimulation of epithelial cells, which simulates tension forces that occur during initial steps of tissue healing, induced Periostin production and mTOR activation. The molecular association of Periostin and mTOR signaling was further dissected by administering rapamycin, a selective pharmacological inhibitor of mTOR, and by disruption of Raptor and Rictor scaffold proteins implicated in the regulation of mTORC1 and mTORC2 complex assembly. Both strategies resulted in ablation of Periostin-induced mitogenic and migratory activity. These results indicate that Periostin-induced epithelial migration and proliferation requires mTOR signaling. Collectively, our findings identify Periostin as a mechanical stress responsive molecule that is primarily secreted by fibroblasts during wound healing and expressed endogenously in epithelial cells resulting in the control of cellular physiology through a mechanism mediated by the mTOR signaling cascade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.