Evidence map›Paper›PMID 24349492›Full record

Trial reportPloS one2013

Sleep-related declarative memory consolidation and verbal replay during sleep talking in patients with REM sleep behavior disorder.

Ginevra Uguccioni, Olivier Pallanca, Jean-Louis Golmard, Pauline Dodet, Bastien Herlin, Smaranda Leu-Semenescu, Isabelle Arnulf

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ginevra UguccioniSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France.
Olivier PallancaSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France.
Jean-Louis GolmardDepartment of Biostatics, Pitié-Salpêtrière Hospital, ER4, Paris 6 University, Paris, France.
Pauline DodetSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France.
Bastien HerlinSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France.
Smaranda Leu-SemenescuSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France.
Isabelle ArnulfSleep Disorder Unit, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France ; Centre de Recherche de l'Institut Cerveau-Moelle épinière, Institut national de la santé et de la recherche médicale Unité 975, Pierre and Marie Curie University ; Institut national de la santé et de la recherche médicale Unités mixtes de recherches 975, Centre national de la recherche scientifique Unités mixtes de recherche 7225, Paris, France ; Institut National de la Santé et de la Recherché Médicale, Unité 975, Paris, France.
Sorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRPitié-Salpêtrière Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine if sleep talkers with REM sleep behavior disorder (RBD) would utter during REM sleep sentences learned before sleep, and to evaluate their verbal memory consolidation during sleep.

methodsEighteen patients with RBD and 10 controls performed two verbal memory tasks (16 words from the Free and Cued Selective Reminding Test and a 220-263 word long modified Story Recall Test) in the evening, followed by nocturnal video-polysomnography and morning recall (night-time consolidation). In 9 patients with RBD, daytime consolidation (morning learning/recall, evening recall) was also evaluated with the modified Story Recall Test in a cross-over order. Two RBD patients with dementia were studied separately. Sleep talking was recorded using video-polysomnography, and the utterances were compared to the studied texts by two external judges.

resultsSleep-related verbal memory consolidation was maintained in patients with RBD (+24±36% words) as in controls (+9±18%, p=0.3). The two demented patients with RBD also exhibited excellent nighttime consolidation. The post-sleep performance was unrelated to the sleep measures (including continuity, stages, fragmentation and apnea-hypopnea index). Daytime consolidation (-9±19%) was worse than night-time consolidation (+29±45%, p=0.03) in the subgroup of 9 patients with RBD. Eleven patients with RBD spoke during REM sleep and pronounced a median of 20 words, which represented 0.0003% of sleep with spoken language. A single patient uttered a sentence that was judged to be semantically (but not literally) related to the text learned before sleep.

conclusionVerbal declarative memory normally consolidates during sleep in patients with RBD. The incorporation of learned material within REM sleep-associated sleep talking in one patient (unbeknownst to himself) at the semantic level suggests a replay at a highly cognitive creative level.

Indexed as

CognitionMemoryAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedREM Sleep Behavior DisorderSleep-Wake Transition Disorders

Identifiers

PMID24349492
PMCPMC3862769
OpenAlexW2013049373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.