Trial reportPloS one2013
Mechanical ventilation drives inflammation in severe viral bronchiolitis.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Respiratory morbidity 6 to 12 months after mechanical ventilation for life-threatening respiratory syncytial virus infection.ERJ open research · 2026Article
- Mean platelet volume as a predictive biomarker for in-hospital mortality in patients receiving invasive mechanical ventilation.BMC pulmonary medicine · 2022Observational
- Mean platelet volume is useful for predicting weaning failure: a retrospective, observational study.BMC anesthesiology · 2022Observational
- Article
- Study of the protective effects of cosmetic ingredients on the skin barrier, based on the expression of barrier-related genes and cytokines.Molecular biology reports · 2022Article
- Pulmonary long-term consequences of COVID-19 infections after hospital discharge.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
- IL-33 and ST2 as predictors of disease severity in children with viral acute lower respiratory infection.Cytokine · 2020Article
- Bacterial co-infection of the respiratory tract in ventilated children with bronchiolitis; a retrospective cohort study.BMC infectious diseases · 2019Article
- Neutrophil/lymphocyte ratio is helpful for predicting weaning failure: a prospective, observational cohort study.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRespiratory insufficiency due to severe respiratory syncytial virus (RSV) infection is the most frequent cause of paediatric intensive care unit admission in infants during the winter season. Previous studies have shown increased levels of inflammatory mediators in airways of mechanically ventilated children compared to spontaneous breathing children with viral bronchiolitis. In this prospective observational multi-center study we aimed to investigate whether this increase was related to disease severity or caused by mechanical ventilation. MATERIALS AND
methodsNasopharyngeal aspirates were collected <1 hour before intubation and 24 hours later in RSV bronchiolitis patients with respiratory failure (n = 18) and non-ventilated RSV bronchiolitis controls (n = 18). Concentrations of the following cytokines were measured: interleukin (IL)-1α, IL-1β, IL-6, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α.
resultsBaseline cytokine levels were comparable between ventilated and non-ventilated infants. After 24 hours of mechanical ventilation mean cytokine levels, except for MIP-1α, were elevated compared to non-ventilated infected controls: IL-1α (159 versus 4 pg/ml, p<0.01), IL-1β (1068 versus 99 pg/ml, p<0.01), IL-6 (2343 versus 958 pg/ml, p<0.05) and MCP-1 (174 versus 26 pg/ml, p<0.05).
conclusionsUsing pre- and post-intubation observations, this study suggests that endotracheal intubation and subsequent mechanical ventilation cause a robust pulmonary inflammation in infants with RSV bronchiolitis.
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