Evidence map›Paper›PMID 24349320›Full record

ArticlePloS one2013

Folate deficiency during early-mid pregnancy affects the skeletal muscle transcriptome of piglets from a reciprocal cross.

Yi Li, Xu Zhang, Yanxiao Sun, Qiang Feng, Guanglei Li, Meng Wang, Xinxing Cui, Li Kang, Yunliang Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yi LiLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China ; The Central Hospital of Taian, Taian, China ; Taian Hospital Affiliated to Taishan Medical University, Taian, China.
Xu ZhangLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Yanxiao SunLaiwu Bureau of Animal Husbandry and Veterinary Medicine, Laiwu, China.
Qiang FengThe Central Hospital of Taian, Taian, China ; Taian Hospital Affiliated to Taishan Medical University, Taian, China.
Guanglei LiLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Meng WangLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Xinxing CuiLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Li KangLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Yunliang JiangLaboratory of Animal Molecular Genetics, College of Animal Science, Shandong Agricultural University, Taian, China.
Shandong Agricultural University · CNTaishan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Folate deficiency (FD) during pregnancy can cause fetal intrauterine growth restriction in pigs, of which the skeletal dysplasia is a major manifestation. Factors influencing muscle development are very important in the formation of porcine meat quality trait. However, the effect of folate deficiency on skeletal muscle development and its molecular mechanisms are unknown. The objective of this study is to determine the effect of maternal folate deficiency on the skeletal muscle transcriptome of piglets from a reciprocal cross, in which full-sibling Landrace (LR) and full-sibling Chinese local breed Laiwu (LW) pigs were used for reciprocal cross matings, and sows were fed either a folate deficient or a normal diet during early-mid gestation. In addition, the difference in the responsiveness of the piglets to folate deficiency during early-mid pregnancy between reciprocal cross groups was investigated. Longissimus dorsi (LD) muscle samples were collected from newborn piglets and a 4 × 44K Agilent porcine oligo microarray was used for transcriptome analysis of porcine LD muscle. The results showed that folate deficiency during early-mid pregnancy affected piglet body weight, LD muscle fiber number and content of intramuscular triglyceride. The microarray results indicated that 3154 genes were differentially expressed between folate deficient and normal piglets from the LR♂ × LW♀ cross, and 3885 differentially expressed genes (DEGs) in the ones from the LW♂ × LR♀ cross. From functional analyses, sow folate deficiency affected almost all biological processes in the progeny. Lipid metabolism-related genes and associated metabolic pathways were regulated extensively by folate deficiency, especially in LR♂ × LW♀ cross piglets. Most of the genes that are regulated by folate deficiency in the LD muscle of piglets were different between LR♂ × LW♀ and LW♂ × LR♀ crosses, suggesting some epigenetic effects of FD exist in genes underlying myogenesis and intramuscular fat deposition in piglets.

Indexed as

Gene Expression ProfilingTranscriptomeAnimalsAnimals, NewbornBreedingCluster AnalysisFemaleFolic Acid DeficiencyGene Expression RegulationMaleMetabolic Networks and PathwaysMuscle, SkeletalPregnancyQuantitative Trait, HeritableReproducibility of ResultsSwine

Identifiers

PMID24349320
PMCPMC3857258
OpenAlexW2010727895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.