ArticlePloS one2013
Is fluid overload more important than diabetes in renal progression in late chronic kidney disease?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis.Renal failure · 2018Pooled it
- Loop diuretics improve conditions of dialysis inception in advanced CKD: an observational cohort study.Journal of nephrology · 2023Observational
- Assessment of Hydration, Nutritional Status and Arterial Stiffness in Hypertensive Chronic Kidney Disease Patients.Nutrients · 2023Article
- Comment on: Long-term hemodialysis improved and stabilized diabetic macular edema: two case reports.International journal of ophthalmology · 2022Article
- Prevalence, awareness, treatment, and control of hypertension in older people: results from the population-based KORA-age 1 study.BMC public health · 2020Article
- Any grade of relative overhydration is associated with long-term mortality in patients with Stages 4 and 5 non-dialysis chronic kidney disease.Clinical kidney journal · 2018Article
- Effect of Strict Volume Control on Renal Progression and Mortality in Non-Dialysis-Dependent Chronic Kidney Disease Patients: A Prospective Interventional Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Article
- Diuretics prescribing in chronic kidney disease patients: physician assessment versus bioimpedence spectroscopy.Clinical and experimental nephrology · 2017Observational
- Article
- Risks of rapid decline renal function in patients with type 2 diabetes.World journal of diabetes · 2014Review
- Bioimpedance spectroscopy for assessment of volume status in patients before and after general anaesthesia.PloS one · 2014Article
- Article
- Diagnostic accuracy of the defining characteristics of the excessive fluid volume diagnosis in hemodialysis patients.Revista latino-americana de enfermagemArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid overload is one of the major presentations in patients with late stage chronic kidney disease (CKD). Diabetes is the leading cause of renal failure, and progression of diabetic nephropathy has been associated with changes in extracellular fluid volume. The aim of the study was to assess the association of fluid overload and diabetes in commencing dialysis and rapid renal function decline (the slope of estimated glomerular filtration rate (eGFR) less than -3 ml/min per 1.73 m(2)/y) in 472 patients with stages 4-5 CKD. Fluid status was determined by bioimpedance spectroscopy method, Body Composition Monitor. The study population was further classified into four groups according to the median of relative hydration status (△HS =fluid overload/extracellular water) and the presence or absence of diabetes. The median level of relative hydration status was 7%. Among all patients, 207(43.9 %) were diabetic. 71 (15.0%) subjects had commencing dialysis, and 187 (39.6%) subjects presented rapid renal function decline during a median 17.3-month follow-up. Patients with fluid overload had a significantly increased risk for commencing dialysis and renal function decline independent of the presence or absence of diabetes. No significantly increased risk for renal progression was found between diabetes and non-diabetes in late CKD without fluid overload. In conclusion, fluid overload has a higher predictive value of an elevated risk for renal progression than diabetes in late CKD.
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