ArticlePloS one2013
Transformation of adaptation and gain rescaling along the whisker sensory pathway.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sensory adaptation in the barrel cortex during active sensation in the behaving mouse.Scientific reports · 2024Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Sensory adaptation mediates efficient and unambiguous encoding of natural stimuli by vestibular thalamocortical pathways.Nature communications · 2022Article
- Dynamics of history-dependent perceptual judgment.Nature communications · 2021Article
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Thalamic state influences timing precision in the thalamocortical circuit.Journal of neurophysiology · 2021Article
- Sensory Adaptation in the Whisker-Mediated Tactile System: Physiology, Theory, and Function.Frontiers in neuroscience · 2021Review
- Cross-Whisker Adaptation of Neurons in Layer 2/3 of the Rat Barrel Cortex.Frontiers in systems neuroscience · 2021Article
- Article
- Prediction of Choice from Competing Mechanosensory and Choice-Memory Cues during Active Tactile Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Design strategies for dynamic closed-loop optogenetic neurocontrol in vivo.Journal of neural engineering · 2018Article
- Organization of sensory feature selectivity in the whisker system.Neuroscience · 2018Review
- Response dynamics of rat barrel cortex neurons to repeated sensory stimulation.Scientific reports · 2017Article
- Multiplexed Spike Coding and Adaptation in the Thalamus.Cell reports · 2017Article
- Review
- Efficient sensory cortical coding optimizes pursuit eye movements.Nature communications · 2016Article
- Input-Specific Gain Modulation by Local Sensory Context Shapes Cortical and Thalamic Responses to Complex Sounds.Neuron · 2016Article
- On-going computation of whisking phase by mechanoreceptors.Nature neuroscience · 2016Article
- A neural mechanism for time-window separation resolves ambiguity of adaptive coding.PLoS biology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurons in all sensory systems have a remarkable ability to adapt their sensitivity to the statistical structure of the sensory signals to which they are tuned. In the barrel cortex, firing rate adapts to the variance of a whisker stimulus and neuronal sensitivity (gain) adjusts in inverse proportion to the stimulus standard deviation. To determine how adaptation might be transformed across the ascending lemniscal pathway, we measured the responses of single units in the first and last subcortical stages, the trigeminal ganglion (TRG) and ventral posterior medial thalamic nucleus (VPM), to controlled whisker stimulation in urethane-anesthetized rats. We probed adaptation using a filtered white noise stimulus that switched between low- and high-variance epochs. We found that the firing rate of both TRG and VPM neurons adapted to stimulus variance. By fitting the responses of each unit to a Linear-Nonlinear-Poisson model, we tested whether adaptation changed feature selectivity and/or sensitivity. We found that, whereas feature selectivity was unaffected by stimulus variance, units often exhibited a marked change in sensitivity. The extent of these sensitivity changes increased systematically along the pathway from TRG to barrel cortex. However, there was marked variability across units, especially in VPM. In sum, in the whisker system, the adaptation properties of subcortical neurons are surprisingly diverse. The significance of this diversity may be that it contributes to a rich population representation of whisker dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.