ArticlePloS one2013
Procalcitonin levels predict acute kidney injury and prognosis in acute pancreatitis: a prospective study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Serum C-reactive protein, procalcitonin, and lactate dehydrogenase for the diagnosis of pancreatic necrosis.The Cochrane database of systematic reviews · 2017Pooled it
- Observational
- Development of a risk prediction model for acute kidney injury in liver transplant recipients.Frontiers in surgery · 2025Article
- Association of serum albumin-to-creatinine ratio with in-hospital mortality in patients with severe acute pancreatitis: a retrospective study.BMC gastroenterology · 2024Article
- Machine learning models for mortality prediction in critically ill patients with acute pancreatitis-associated acute kidney injury.Clinical kidney journal · 2024Article
- Development and validation of a prediction model for the early occurrence of acute kidney injury in patients with acute pancreatitis.Renal failure · 2023Article
- Role of the SARS‑COV2 infection in the evolution of acute pancreatitis (Review).Biomedical reports · 2023Review
- Diagnostic and Prognostic Roles of C-Reactive Protein, Procalcitonin, and Presepsin in Acute Kidney Injury Patients Initiating Continuous Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2023Article
- SARS-CoV-2 and the pancreas: What do we know about acute pancreatitis in COVID-19 positive patients?World journal of gastroenterology · 2022Article
- Study of the protective effects of cosmetic ingredients on the skin barrier, based on the expression of barrier-related genes and cytokines.Molecular biology reports · 2022Article
- Assessing the value of serum and urinary interleukins for diagnosis of acute kidney injury in children and adolescents: A systematic review and meta-analysis.Practical laboratory medicine · 2022Review
- Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis.World journal of clinical cases · 2021Article
- Analysis of the diagnostic capabilities of urinary neutrophil gelatinase-associated lipocalin and serum procalcitonin for acute kidney injury at the early stage of critical care intensive care unit admission.Journal of clinical laboratory analysis · 2021Article
- Predictive Ability of Procalcitonin for Acute Kidney Injury: A Narrative Review Focusing on the Interference of Infection.International journal of molecular sciences · 2021Review
- A risk score based on procalcitonin for predicting acute kidney injury in COVID-19 patients.Journal of clinical laboratory analysis · 2021Article
- Combination of biomarker with clinical risk factors for prediction of severe acute kidney injury in critically ill patients.BMC nephrology · 2020Article
- Independent Predictive Ability of Procalcitonin of Acute Kidney Injury among Critically Ill Patients.Journal of clinical medicine · 2020Article
- The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study.Journal of clinical medicine · 2020Article
- Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis.International journal of molecular sciences · 2019Review
- Effect of Segmental Thoracic Epidural Block on Pancreatitisinduced Organ Dysfunction: A Preliminary Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) has been proposed as a leading cause of mortality for acute pancreatitis (AP) patients admitted to the intensive care unit (ICU). This study investigated the predictive value of procalcitonin (PCT) for AKI development and relevant prognosis in patients with AP, and compared PCT's predictive power with that of other inflammation-related variables.
methodsBetween January 2011 and March 2013, we enrolled 305 cases with acute pancreatitis admitted to ICU. Serum levels of PCT, serum amyloid A (SAA), interleukin-6 (IL-6), and C reactive protein (CRP) were determined on admission. Serum PCT was tested in patients who developed AKI on the day of AKI occurrence and on either day 28 after occurrence (for survivors) or on the day of death (for those who died within 28 days).
resultsSerum PCT levels were 100-fold higher in the AKI group than in the non-AKI group on the day of ICU admission (p<0.05). The area under the receiver-operating characteristic (ROC) curve of PCT for predicting AKI was 0.986, which was superior to SAA, CRP, and IL-6 (p<0.05). ROC analysis revealed all variables tested had lower predictive performance for AKI prognosis. The average serum PCT level on day 28 (2.67 (0.89, 7.99) ng/ml) was significantly (p<0.0001) lower than on the day of AKI occurrence (43.71 (19.24,65.69) ng/ml) in survivors, but the serum PCT level on death (63.73 (34.22,94.30) ng/ml) was higher than on the day of AKI occurrence (37.55 (18.70,74.12) ng/ml) in non-survivors, although there was no significant difference between the two days in the latter group (p = 0.1365).
conclusionSerum PCT is superior to CRP, IL-6, and SAA for predicting the development of AKI in patients with AP, and also can be used for dynamic evaluation of AKI prognosis.
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