ArticlePloS one2013
Factors associated with failed treatment: an analysis of 121,744 women embarking on their first IVF cycles.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Assisted Oocyte Activation With Calcium Ionophore Improves Pregnancy Outcomes and Offspring Safety in Infertile Patients: A Systematic Review and Meta-Analysis.Frontiers in physiology · 2021Pooled it
- The effects of acupuncture on pregnancy outcomes of in vitro fertilization: a systematic review and meta-analysis.BMC complementary and alternative medicine · 2019Pooled it
- Effects of cumulus cell removal time during in vitro fertilization on embryo quality and pregnancy outcomes: a prospective randomized sibling-oocyte study.Reproductive biology and endocrinology : RB&E · 2016Trial
- Person-Centered Exploration of Neonatal Intensive Care Unit Stressors and Social Support in Parenting Very Preterm Infants: A Cross-Sectional Study on Risks and Resources in Italy and Portugal.Children (Basel, Switzerland) · 2026Article
- Observational cohort study exploring MediEmo smartphone application use, live birth, and in vitro fertilization treatment return rates.F&S reports · 2025Article
- Aggressive sperm immobilization improves reproductive outcomes in patients with suboptimal semen parameters and previous ICSI fertilization failure.Scientific reports · 2024Article
- High rate of detected variants in maleHuman reproduction open · 2024Article
- Significant differences in efficiency between two commonly used ionophore solutions for assisted oocyte activation (AOA): a prospective comparison of ionomycin and A23187.Journal of assisted reproduction and genetics · 2023Article
- Strategies in Infertile Azoospermic Patients with Negative Microdissection Testicular Sperm Extraction Surgery.Urology research & practice · 2023Article
- Unraveling female reproductive senescence to enhance healthy longevity.Cell research · 2023Review
- Association between oocyte retrieval technique and number of oocytes retrieved.Journal of assisted reproduction and genetics · 2022Article
- Is Blastocyst Culture Responsible for Higher Pregnancy Rates? A Critical Analysis of the Day of Optimal Embryo Transfer and Embryo Quality.JBRA assisted reproduction · 2022Article
- Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI.Journal of assisted reproduction and genetics · 2022Article
- Comparison of the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing in vitro fertilization using a standardized stimulation regime.Journal of ovarian research · 2021Article
- Observational
- Factors Associated with In Vitro Fertilization Live Birth Outcome: A Comparison of Different Classification Methods.International journal of fertility & sterility · 2021Article
- Unexplained infertility categorization based on female laparoscopy and total motile sperm count, and its impact on cumulative live-births after one in-vitro fertilization cycle. A retrospective cohort study involving 721 cycles.Reproductive medicine and biology · 2021Article
- The outcome of IVF/ICSI cycles in male cancer patients: retrospective analysis of procedures from 2004 to 2018.Radiology and oncology · 2021Article
- IVF or ICSI for fertility preservation?Reproduction & fertility · 2021Article
- Diagnosis and Treatment of Male Infertility-Related Fertilization Failure.Journal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn-vitro fertilization (IVF) is the treatment of choice for unresolved infertility. It comprises a number of key steps, each of which has to be negotiated before the next is attempted, but the factors which are associated with failure at each stage have not been reported. METHODS AND
findingsWe analyzed anonymised national data on women undergoing their first fresh autologous IVF and intracytoplasmic sperm injection (ICSI) cycle in the United Kingdom between 2000 and 2007 to predict factors associated with overall lack of livebirth as well as the chance of non-progress at different stages of an IVF cycle. A total of 121,744 women were included in this analysis. Multivariable models underlined the importance of increased female age and duration of infertility, lack of previous pregnancy, and a diagnosis of tubal or male factor infertility in predicting the risk of not having a live birth in an IVF treatment. At each stage, a woman's chance of proceeding to the next stage of IVF treatment is affected by increased age and duration of infertility. The intention to use intra-cytoplasmic sperm injection (ICSI) is associated with a decreased risk of treatment failure in women starting an IVF cycle (RR 0.93, 99% CI 0.92, 0.94) but this association is reversed at a later stage once fertilisation has been confirmed (RR=1.01, 99%CI 1.00, 1.03).
conclusionsFemale age is a key predictor of failure to have a livebirth following IVF as well as the risk of poor performance at each stage of treatment. While increased duration of infertility is also associated with worse outcomes at every stage, its impact appears to be less influential. Women embarking on ICSI treatment for male factor infertility have a lower chance of treatment failure but this does not appear to be due to increased chances of implantation of ICSI embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.