ArticlePloS one2013
Common neural mechanisms underlying reversal learning by reward and punishment.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Dopaminergic Treatment and Episodic Memory in Parkinson's Disease: A Meta-analysis of the Literature.Neuropsychology review · 2025Pooled it
- Hot and Cool Executive Functions in Middle Childhood: Evidence for a Weak but Process-Specific Relationship.Children (Basel, Switzerland) · 2026Article
- Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa.Cognitive, affective & behavioral neuroscience · 2026Article
- Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults.Brain structure & function · 2026Article
- Frontal EEG Asymmetry and Attachment Style During Sequential Decision-Making in the Secretary Problem.Behavioral sciences (Basel, Switzerland) · 2026Article
- Resting-state brain function and its modulation by intranasal oxytocin in antisocial personality disorder with and without psychopathy.Scientific reports · 2026Article
- Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Material hardship, not household income, predicts impaired punishment learning: a computational reinforcement learning perspective.Frontiers in psychology · 2025Article
- Assessing cognitive flexibility in humans and rhesus macaques with visual motion and neutral distractors.Frontiers in psychology · 2022Article
- Observational
- Effective connectivity underlying reward-based executive control.Human brain mapping · 2021Article
- Subcortical Dopamine and Cognition in Schizophrenia: Looking Beyond Psychosis in Preclinical Models.Frontiers in neuroscience · 2020Review
- Differential modulation of cognitive control networks by monetary reward and punishment.Social cognitive and affective neuroscience · 2019Article
- Internet Game Overuse Is Associated With an Alteration of Fronto-Striatal Functional Connectivity During Reward Feedback Processing.Frontiers in psychiatry · 2018Article
- Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder.Physiology & behavior · 2017Article
- Development, Initial Testing and Challenges of an Ecologically Valid Reward Prediction Error FMRI Task for Alcoholism.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Article
- Clinical Depression and Punishment Sensitivity on the BART.Frontiers in psychology · 2017Article
- Neural correlates of maintaining one's political beliefs in the face of counterevidence.Scientific reports · 2016Article
- Reversal Learning in Humans and Gerbils: Dynamic Control Network Facilitates Learning.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Impairments in flexible goal-directed decisions, often examined by reversal learning, are associated with behavioral abnormalities characterized by impulsiveness and disinhibition. Although the lateral orbital frontal cortex (OFC) has been consistently implicated in reversal learning, it is still unclear whether this region is involved in negative feedback processing, behavioral control, or both, and whether reward and punishment might have different effects on lateral OFC involvement. Using a relatively large sample (N = 47), and a categorical learning task with either monetary reward or moderate electric shock as feedback, we found overlapping activations in the right lateral OFC (and adjacent insula) for reward and punishment reversal learning when comparing correct reversal trials with correct acquisition trials, whereas we found overlapping activations in the right dorsolateral prefrontal cortex (DLPFC) when negative feedback signaled contingency change. The right lateral OFC and DLPFC also showed greater sensitivity to punishment than did their left homologues, indicating an asymmetry in how punishment is processed. We propose that the right lateral OFC and anterior insula are important for transforming affective feedback to behavioral adjustment, whereas the right DLPFC is involved in higher level attention control. These results provide insight into the neural mechanisms of reversal learning and behavioral flexibility, which can be leveraged to understand risky behaviors among vulnerable populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.