Trial reportPloS one2013
Electrical vestibular stimulation after vestibular deafferentation and in vestibular schwannoma.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Vestibular implant: does it really work? A systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Galvanic vestibular stimulation promotes visuospatial cognitive recovery in acute unilateral vestibulopathy via targeted neural modulation: a randomized controlled trial.Journal of translational medicine · 2025Trial
- Comparison of postural responses to galvanic vestibular stimulation between pilots and the general populace.BioMed research international · 2015Trial
- Complications of microsurgery of vestibular schwannoma.BioMed research international · 2014Trial
- Optimising electrical vestibular stimulation (EVS) for assessing vestibular function.Clinical neurophysiology practice · 2025Article
- The Neural Basis for Biased Behavioral Responses Evoked by Galvanic Vestibular Stimulation in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Thresholds for vestibular and cutaneous perception and oculomotor response induced by galvanic vestibular stimulation.Frontiers in neurology · 2022Article
- Enhanced Eye Velocity in Head Impulse Testing-A Possible Indicator of Endolymphatic Hydrops.Frontiers in surgery · 2021Article
- Effects of Galvanic Vestibular Stimulation on Vestibular Compensation in Unilaterally Labyrinthectomized Mice.Frontiers in neurology · 2021Article
- The Anatomical and Physiological Basis of Clinical Tests of Otolith Function. A Tribute to Yoshio Uchino.Frontiers in neurology · 2020Review
- Asymmetric Unilateral Vestibular Perception in Adolescents With Idiopathic Scoliosis.Frontiers in neurology · 2019Article
- Comparing Ocular Responses to Caloric Irrigation and Electrical Vestibular Stimulation in Vestibular Schwannoma.Frontiers in neurology · 2019Article
- Ocular torsion responses to electrical vestibular stimulation in vestibular schwannoma.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Ocular torsion responses to sinusoidal electrical vestibular stimulation.Journal of neuroscience methods · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVestibular reflexes, evoked by human electrical (galvanic) vestibular stimulation (EVS), are utilized to assess vestibular function and investigate its pathways. Our study aimed to investigate the electrically-evoked vestibulo-ocular reflex (eVOR) output after bilateral and unilateral vestibular deafferentations to determine the characteristics for interpreting unilateral lesions such as vestibular schwannomas.
methodsEVOR was recorded with dual-search coils as binocular three-dimensional eye movements evoked by bipolar 100 ms-step at EVS intensities of [0.9, 2.5, 5.0, 7.5, 10.0] mA and unipolar 100 ms-step at 5 mA EVS intensity. Five bilateral vestibular deafferented (BVD), 12 unilateral vestibular deafferented (UVD), four unilateral vestibular schwannoma (UVS) patients and 17 healthy subjects were tested with bipolar EVS, and five UVDs with unipolar EVS.
resultsAfter BVD, bipolar EVS elicited no eVOR. After UVD, bipolar EVS of one functioning ear elicited bidirectional, excitatory eVOR to cathodal EVS with 9 ms latency and inhibitory eVOR to anodal EVS, opposite in direction, at half the amplitude with 12 ms latency, exhibiting an excitatory-inhibitory asymmetry. The eVOR patterns from UVS were consistent with responses from UVD confirming the vestibular loss on the lesion side. Unexpectedly, unipolar EVS of the UVD ear, instead of absent response, evoked one-third the bipolar eVOR while unipolar EVS of the functioning ear evoked half the bipolar response.
conclusionsThe bidirectional eVOR evoked by bipolar EVS from UVD with an excitatory-inhibitory asymmetry and the 3 ms latency difference between normal and lesion side may be useful for detecting vestibular lesions such as UVS. We suggest that current spread could account for the small eVOR to 5 mA unipolar EVS of the UVD ear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.