ArticlePloS one2013
Evaluation of cytotoxic and anti-inflammatory activities of extracts and lectins from Moringa oleifera seeds.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Biological properties ofF1000Research · 2024Pooled it
- Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review of Recent Studies and Possible Mechanism of Actions.Frontiers in pharmacology · 2022Pooled it
- Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan-Induced Diabetic Mice.Journal of applied toxicology : JAT · 2026Article
- Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains.Journal of applied toxicology : JAT · 2026Article
- Biodiversity and genetic improvement ofFrontiers in plant science · 2026Review
- Beyond Antioxidant Activity: Redox-Inflammatory Network Modulation as a Framework for the Multi-Organ Pharmacology ofJournal of experimental pharmacology · 2026Review
- Preclinical Risk Assessment of Plant Lectins with Pharmacological Applications: A Narrative Review.Molecules (Basel, Switzerland) · 2025Review
- Biological Activities and Phenolic Profile ofPlants (Basel, Switzerland) · 2025Article
- Effects of Heat Treatment on Physicochemical Properties ofInternational journal of molecular sciences · 2025Article
- Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice.Histology and histopathology · 2024Article
- Microparticles Loaded withPharmaceuticals (Basel, Switzerland) · 2024Article
- From inflammation to immune regulation: The dual nature of dietary lectins in health and disease.Heliyon · 2024Review
- Carbohydrate-Binding Mechanism of the Coagulant Lectin fromMolecules (Basel, Switzerland) · 2024Article
- Moringa oleifera flowers: insights into their aroma chemistry, anti-inflammatory, antioxidant, and enzyme inhibitory properties.BMC complementary medicine and therapies · 2024Article
- Promising Influences ofEndocrine, metabolic & immune disorders drug targets · 2024Review
- Development, characterization, and immunomodulation performance of spray-dried Moringa oleifera seed extract in Longfin yellowtail Seriola rivoliana.Veterinary research communications · 2023Article
- Antimicrobial activity of the Flo peptide produced in Scenedesmus acutus and Nannochloropsis oculata.World journal of microbiology & biotechnology · 2023Article
- Chemical Analysis and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2022Article
- A Comprehensive Review with Updated Future Perspectives on the Ethnomedicinal and Pharmacological Aspects ofMolecules (Basel, Switzerland) · 2022Review
- Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated withNutrients · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe extract from Moringa oleifera seeds is used worldwide, especially in rural areas of developing countries, to treat drinking water. M. oleifera seeds contain the lectins cmol and WSMoL, which are carbohydrate-binding proteins that are able to reduce water turbidity because of their coagulant activity. Studies investigating the ability of natural products to damage normal cells are essential for the safe use of these substances. This study evaluated the cytotoxic and anti-inflammatory properties of the aqueous seed extract, the extract used by population to treat water (named diluted seed extract in this work), and the isolated lectins cmol and WSMoL. METHODOLOGY/PRINCIPAL
findingsThe data showed that the aqueous seed extract and cmol were potentially cytotoxic to human peripheral blood mononuclear cells, while WSMoL and diluted seed extract were not cytotoxic. The M. oleifera aqueous seed extract and the lectins cmol and WSMoL were weakly/moderately cytotoxic to the NCI-H292, HT-29 and HEp-2 cancer cell lines and were not hemolytic to murine erythrocytes. Evaluation of acute toxicity in mice revealed that the aqueous seed extract (2.000 mg/kg) did not cause systemic toxicity. The aqueous seed extract, cmol and WSMoL (6.25 µg/mL) and diluted seed extract at 50 µg/mL exhibited anti-inflammatory activity on lipopolyssaccharide-stimulated murine macrophages by regulating the production of nitric oxide, TNF-α and IL-1β. The aqueous seed extract reduced leukocyte migration in a mouse model of carrageenan-induced pleurisy; the myeloperoxidase activity and nitric oxide, TNF-α and IL-1β levels were similarly reduced. Histological analysis of the lungs showed that the extract reduced the number of leukocytes. CONCLUSION/SIGNIFICANCE: This study shows that the extract prepared according to folk use and WSMoL may be non-toxic to mammalian cells; however, the aqueous seed extract and cmol may be cytotoxic to immune cells which may explain the immunosuppressive potential of the extract.
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