ArticlePloS one2013
Influence of lifestyle factors on mammographic density in postmenopausal women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.Carcinogenesis · 2020Trial
- Article
- WHO-recommended levels of physical activity in relation to mammographic breast density, mammographic tumor appearance, and mode of detection of breast cancer.Breast cancer research : BCR · 2024Article
- Mammographic density in relationships with relevant contributing factors: a multicentric study from Riyadh, Saudi Arabia.Gland surgery · 2024Article
- Associations of alcohol consumption with breast tissue composition.Breast cancer research : BCR · 2023Article
- Factors Influencing Mammographic Density in Asian Women: A Retrospective Cohort Study in the Northeast Region of Peninsular Malaysia.Diagnostics (Basel, Switzerland) · 2022Article
- The epidemiologic factors associated with breast density: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
- The Relationship Between Mammographic Density and Factors Affecting Breast Cancer Risk.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk.JNCI cancer spectrum · 2021Article
- Alcohol and Tobacco Use in Relation to Mammographic Density in 23,456 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer.BMC cancer · 2019Article
- Mammographic Density and Screening Sensitivity, Breast Cancer Incidence and Associated Risk Factors in Danish Breast Cancer Screening.Journal of clinical medicine · 2019Article
- Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy.Breast cancer research : BCR · 2019Article
- Predictors of mammographic density among women with a strong family history of breast cancer.BMC cancer · 2019Article
- Determinants of Mammographic Density Change.JNCI cancer spectrum · 2019Article
- Interactions of alcohol and postmenopausal hormone use in regards to mammographic breast density.Cancer causes & control : CCC · 2018Article
- Breast cancer risk factors and mammographic density among high-risk women in urban China.NPJ breast cancer · 2018Article
- Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium.Breast cancer research : BCR · 2017Article
- Alcohol intake from early adulthood to midlife and mammographic density.Cancer causes & control : CCC · 2016Article
- Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women.Breast cancer research : BCR · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammographic density is a strong risk factor for breast cancer. Apart from hormone replacement therapy (HRT), little is known about lifestyle factors that influence breast density.
methodsWe examined the effect of smoking, alcohol and physical activity on mammographic density in a population-based sample of postmenopausal women without breast cancer. Lifestyle factors were assessed by a questionnaire and percentage and area measures of mammographic density were measured using computer-assisted software. General linear models were used to assess the association between lifestyle factors and mammographic density and effect modification by body mass index (BMI) and HRT was studied.
resultsOverall, alcohol intake was positively associated with percent mammographic density (P trend = 0.07). This association was modified by HRT use (P interaction = 0.06): increasing alcohol intake was associated with increasing percent density in current HRT users (P trend = 0.01) but not in non-current users (P trend = 0.82). A similar interaction between alcohol and HRT was found for the absolute dense area, with a positive association being present in current HRT users only (P interaction = 0.04). No differences in mammographic density were observed across categories of smoking and physical activity, neither overall nor in stratified analyses by BMI and HRT use.
conclusionsIncreasing alcohol intake is associated with an increase in mammography density, whereas smoking and physical activity do not seem to influence density. The observed interaction between alcohol and HRT may pose an opportunity for HRT users to lower their mammographic density and breast cancer risk.
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