ArticlePloS one2013
Metarhizium anisopliae pathogenesis of mosquito larvae: a verdict of accidental death.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 127 citations in OpenAlex.
- A mycovirus shaped insect-pathogenic and non-pathogenic phenotypes in a fungal biocontrol agent.Virulence · 2026Article
- The potential of Clonostachys rosea as a biolarvicide against Anopheles gambiae.Journal of invertebrate pathology · 2026Article
- A broad-spectrum Chromobacterium biolarvicide formulation disrupts mosquito development through gut damage and apoptotic cell death and compromises vector competence.Communications biology · 2026Article
- Screening and Comparative Efficacy of Indigenous Entomopathogenic Fungi from Forest Ecosystems AgainstInsects · 2026Article
- Maternal and cross-stage effects of Metarhizium pingshaense fungal infection on the malaria mosquito Anopheles coluzzii life-history.PloS one · 2026Article
- Discovery of a fungal Tc toxin complex and functional mycoserpin through a novel two-by-two comparative genomics approach.Frontiers in cellular and infection microbiology · 2026Article
- Review
- Larvicidal and Immunomodulatory Effects of Conidia and Blastospores ofJournal of fungi (Basel, Switzerland) · 2025Article
- Visualizing Oral Infection Dynamics ofJournal of fungi (Basel, Switzerland) · 2025Article
- Encapsulation of Beauveria bassiana conidia as a new strategy for the biological control of Aedes aegypti larvae.Scientific reports · 2024Article
- In Vitro Assessment of Metarhizium Anisopliae Pathogenicity Against Aedes Aegypti Life Stages.Neotropical entomology · 2024Article
- General aspects, host interaction, and application ofFrontiers in fungal biology · 2024Review
- Transcriptomic landscape of the interaction between the entomopathogenic fungus Beauveria bassiana and its tolerant host Tribolium castaneum revealed by dual RNA-seq.Scientific reports · 2023Article
- Article
- Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction in Vector Competence.Insects · 2023Review
- The Potential ofJournal of fungi (Basel, Switzerland) · 2023Article
- A Novel Model of Pathogenesis ofInsects · 2023Article
- Optimizing the Application Timing and Dosage of Metarhizium brunneum (Hypocreales: Clavicipitaceae) as a Biological Control Agent of Aedes aegypti (Diptera: Culicidae) Larvae.Journal of medical entomology · 2023Article
- Beauveria bassiana interacts with gut and hemocytes to manipulate Aedes aegypti immunity.Parasites & vectors · 2023Article
- Stress-Mediated Responses of Aedes aegypti (Diptera: Culicidae) Larvae When Exposed to Metarhizium brunneum (Hypocreales: Clavicipitaceae) and Toxorhynchites brevipalpis (Diptera: Culicidae).Journal of medical entomology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metarhizium anisopliae, a fungal pathogen of terrestrial arthropods, kills the aquatic larvae of Aedes aegypti, the vector of dengue and yellow fever. The fungus kills without adhering to the host cuticle. Ingested conidia also fail to germinate and are expelled in fecal pellets. This study investigates the mechanism by which this fungus adapted to terrestrial hosts kills aquatic mosquito larvae. Genes associated with the M. anisopliae early pathogenic response (proteinases Pr1 and Pr2, and adhesins, Mad1 and Mad2) are upregulated in the presence of larvae, but the established infection process observed in terrestrial hosts does not progress and insecticidal destruxins were not detected. Protease inhibitors reduce larval mortality indicating the importance of proteases in the host interaction. The Ae. aegypti immune response to M. anisopliae appears limited, whilst the oxidative stress response gene encoding for thiol peroxidase is upregulated. Cecropin and Hsp70 genes are downregulated as larval death occurs, and insect mortality appears to be linked to autolysis through caspase activity regulated by Hsp70 and inhibited, in infected larvae, by protease inhibitors. Evidence is presented that a traditional host-pathogen response does not occur as the species have not evolved to interact. M. anisopliae retains pre-formed pathogenic determinants which mediate host mortality, but unlike true aquatic fungal pathogens, does not recognise and colonise the larval host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.