ArticlePloS one2013
Recipe for a busy bee: microRNAs in Honey Bee caste determination.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 85 citations in OpenAlex.
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Article
- Epigenetic Mechanisms inCurrent issues in molecular biology · 2025Review
- The eusocial non-code: Unveiling the impact of noncoding RNAs on Hymenoptera eusocial evolution.Non-coding RNA research · 2025Review
- De Novo miRNAs fromInsects · 2024Article
- Regulation of soldier caste differentiation by microRNAs in Formosan subterranean termite (PeerJ · 2024Article
- MicroRNA profiling of royal jelly extracellular vesicles and their potential role in cell viability and reversing cell apoptosis.Functional & integrative genomics · 2023Article
- Article
- Phenotypic dimorphism between honeybee queen and worker is regulated by complicated epigenetic modifications.iScience · 2023Article
- Identification and profiling of stable microRNAs in hemolymph of young and oldCurrent research in insect science · 2022Article
- Contribution of Epigenetic Mechanisms in the Regulation of Environmentally-Induced Polyphenism in Insects.Insects · 2021Review
- The role of epigenetics, particularly DNA methylation, in the evolution of caste in insect societies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- RNAs on the Go: Extracellular Transfer in Insects with Promising Prospects for Pest Management.Plants (Basel, Switzerland) · 2021Review
- Epigenetic Molecular Mechanisms in Insects.Neotropical entomology · 2020Review
- Small RNAs in eucaryotes: new clues for amplifying microRNA benefits.Cell & bioscience · 2020Review
- Special Significance of Non-Frontiers in cell and developmental biology · 2020Review
- The presence of extracellular microRNAs in the media of cultured Drosophila cells.Scientific reports · 2018Article
- Influence of the Neonicotinoid Insecticide Thiamethoxam on miRNA Expression in the Honey Bee (Hymenoptera: Apidae).Journal of insect science (Online) · 2017Article
- Uptake and impact of natural diet-derived small RNA in invertebrates: Implications for ecology and agriculture.RNA biology · 2017Review
- MicroRNAs Associated with Caste Determination and Differentiation in a Primitively Eusocial Insect.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social caste determination in the honey bee is assumed to be determined by the dietary status of the young larvae and translated into physiological and epigenetic changes through nutrient-sensing pathways. We have employed Illumina/Solexa sequencing to examine the small RNA content in the bee larval food, and show that worker jelly is enriched in miRNA complexity and abundance relative to royal jelly. The miRNA levels in worker jelly were 7-215 fold higher than in royal jelly, and both jellies showed dynamic changes in miRNA content during the 4(th) to 6(th) day of larval development. Adding specific miRNAs to royal jelly elicited significant changes in queen larval mRNA expression and morphological characters of the emerging adult queen bee. We propose that miRNAs in the nurse bee secretions constitute an additional element in the regulatory control of caste determination in the honey bee.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.