Evidence map›Paper›PMID 24349030›Full record

ArticlePloS one2013

A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder.

Carla P D Fernandes, Andrea Christoforou, Sudheer Giddaluru, Kari M Ersland, Srdjan Djurovic, Manuel Mattheisen, Astri J Lundervold, Ivar Reinvang, Markus M Nöthen, Marcella Rietschel and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. A systematic review of ENT retractions.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Pooled it
  2. Review
  3. Article
  4. A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018
    Article
  5. Article
  6. Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 5 countries.

Carla P D FernandesK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Andrea ChristoforouK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Sudheer GiddaluruK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Kari M ErslandK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Srdjan DjurovicK. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Manuel MattheisenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany ; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America ; Institute for Genomic Mathematics, University of Bonn, Bonn, Germany.
Astri J LundervoldDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway ; Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway ; K. G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
Ivar ReinvangDepartment of Psychology, University of Oslo, Oslo, Norway.
Markus M NöthenDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany ; Institute of Human Genetics, University of Bonn, Bonn, Germany ; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Roel A OphoffDepartment of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands ; Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California, United States of America.
Genetic Risk and Outcome of Psychosis (GROUP)
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands ; Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Thomas WergeMental Health Centre Sct. Hans, Copenhagen University Hospital, Research Institute of Biological Psychiatry, Roskilde, Denmark.
Sven CichonDepartment of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany ; Institute of Human Genetics, University of Bonn, Bonn, Germany ; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.
Thomas EspesethK. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Department of Psychology, University of Oslo, Oslo, Norway.
Ole A AndreassenK. G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway ; Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Vidar M SteenK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Stephanie Le HellardK. G. Jebsen Centre for Psychosis Research and the Norwegian Centre for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway ; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Haukeland University Hospital · NOOslo University Hospital · NOErasmus MC · NLUniversity of Bonn · DEBrigham and Women's Hospital · USHeidelberg University · DEUniversity of Bergen · NOUniversity of California, Los Angeles · USUniversity of Oslo · NO

Funding

Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA StudiesR01MH081862 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI LANGE, CHRISTOPH · 2009 to 2014
$2.0M
A New Approach to Mental Health Phenotypes in Family Genomewide AssociationR01MH087590 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI LANGE, CHRISTOPH · 2010 to 2013
$1.6M
NHLBI NIH HHS U01 HL089856NIMH NIH HHS R01 MH081862NIMH NIH HHS R01 MH087590
6 · The paper itself

Abstract

backgroundImpairments in cognitive functions are common in patients suffering from psychiatric disorders, such as schizophrenia and bipolar disorder. Cognitive traits have been proposed as useful for understanding the biological and genetic mechanisms implicated in cognitive function in healthy individuals and in the dysfunction observed in psychiatric disorders.

methodsSets of genes associated with a range of cognitive functions often impaired in schizophrenia and bipolar disorder were generated from a genome-wide association study (GWAS) on a sample comprising 670 healthy Norwegian adults who were phenotyped for a broad battery of cognitive tests. These gene sets were then tested for enrichment of association in GWASs of schizophrenia and bipolar disorder. The GWAS data was derived from three independent single-centre schizophrenia samples, three independent single-centre bipolar disorder samples, and the multi-centre schizophrenia and bipolar disorder samples from the Psychiatric Genomics Consortium.

resultsThe strongest enrichments were observed for visuospatial attention and verbal abilities sets in bipolar disorder. Delayed verbal memory was also enriched in one sample of bipolar disorder. For schizophrenia, the strongest evidence of enrichment was observed for the sets of genes associated with performance in a colour-word interference test and for sets associated with memory learning slope.

conclusionsOur results are consistent with the increasing evidence that cognitive functions share genetic factors with schizophrenia and bipolar disorder. Our data provides evidence that genetic studies using polygenic and pleiotropic models can be used to link specific cognitive functions with psychiatric disorders.

Indexed as

AdolescentAdultAgedBipolar DisorderFemaleGenome-Wide Association StudyHumansMaleMiddle AgedNeuropsychological TestsSchizophreniaSchizophrenic PsychologyYoung Adult

Identifiers

PMID24349030
PMCPMC3861303
OpenAlexW2171798976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.