ArticlePloS one2013
The transcriptomics of glucocorticoid receptor signaling in developing zebrafish.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Egg-mediated maternal effects in a cooperatively breeding cichlid fish.Scientific reports · 2023Article
- Neuronal and Astroglial Localization of Glucocorticoid Receptor GRα in Adult Zebrafish Brain (Brain sciences · 2023Article
- Zebrafish parental progeny investment in response to cycling thermal stress and hypoxia: deposition of heat shock proteins but not cortisol.The Journal of experimental biology · 2022Article
- Chronic cortisol exposure in early development leads to neuroendocrine dysregulation in adulthood.BMC research notes · 2020Article
- Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2018Article
- Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish.Scientific reports · 2017Article
- Maternal Cortisol Mediates Hypothalamus-Pituitary-Interrenal Axis Development in Zebrafish.Scientific reports · 2016Article
- Proteomics of Xenopus development.Molecular human reproduction · 2016Article
- Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells.PloS one · 2016Article
- PER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity.Frontiers in psychology · 2016Article
- mRNA-seq reveals skeletal muscle atrophy in response to handling stress in a marine teleost, the red cusk-eel (Genypterus chilensis).BMC genomics · 2015Article
- Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart.Molecular and cellular endocrinology · 2015Article
- Osmoregulation in zebrafish: ion transport mechanisms and functional regulation.EXCLI journal · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortisol is the primary corticosteroid in teleosts that is released in response to stressor activation of the hypothalamus-pituitary-interrenal axis. The target tissue action of this hormone is primarily mediated by the intracellular glucocorticoid receptor (GR), a ligand-bound transcription factor. In developing zebrafish (Danio rerio) embryos, GR transcripts and cortisol are maternally deposited into the oocyte prior to fertilization and influence early embryogenesis. To better understand of the molecular mechanisms involved, we investigated changes in the developmental transcriptome prior to hatch, in response to morpholino oligonucleotide knockdown of GR using the Agilent zebrafish microarray platform. A total of 1313 and 836 mRNA transcripts were significantly changed at 24 and 36 hours post fertilization (hpf), respectively. Functional analysis revealed numerous developmental processes under GR regulation, including neurogenesis, eye development, skeletal and cardiac muscle formation. Together, this study underscores a critical role for glucocorticoid signaling in programming molecular events essential for zebrafish development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.