ArticleCellular and molecular bioengineering2013
Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.
Article in Cellular and molecular bioengineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer.Cancer research · 2024Article
- A Graphical Approach to Visualize and Interpret Biochemically Coupled Biomechanical Models.Journal of biomechanical engineering · 2024Article
- A computational bridge between traction force microscopy and tissue contraction.Journal of applied physics · 2023Article
- A structural bio-chemo-mechanical model for vascular smooth muscle cell traction force microscopy.Biomechanics and modeling in mechanobiology · 2023Article
- Review
- Stiffness Sensing by Cells.Physiological reviews · 2020Review
- Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility.Journal of cell science · 2020Article
- Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making.Nature communications · 2019Article
- MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.Journal of cellular and molecular medicine · 2019Article
- Quantitative assessment of cell contractility using polarized light microscopy.Journal of biophotonics · 2018Article
- The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation.Scientific reports · 2018Article
- Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin.Cellular and molecular bioengineering · 2018Article
- Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis.Cell adhesion & migration · 2018Review
- Regulation of circular dorsal ruffles, macropinocytosis, and cell migration by RhoG and its exchange factor, Trio.Molecular biology of the cell · 2017Article
- Horizontal alignment of 5' -> 3' intergene distance segment tropy with respect to the gene as the conserved basis for DNA transcription.Future science OA · 2017Article
- Matrix stiffening promotes a tumor vasculature phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Matrix Stiffness Enhances VEGFR-2 Internalization, Signaling, and Proliferation in Endothelial Cells.Convergent science physical oncology · 2017Article
- Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.Trends in cell biology · 2016Review
- Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility.Journal of biomechanics · 2016Article
- Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration.Molecular biology of the cell · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
As atherosclerosis progresses, vascular smooth muscle cells (VSMCs) invade from the medial layer into the intimal layer and proliferate, contributing to atherosclerotic plaque formation. This migration is stimulated in part by platelet-derived growth factor (PDGF), which is released by endothelial cells and inflammatory cells, and vessel stiffening, which occurs with age and atherosclerosis progression. PDGF induces the formation of circular dorsal ruffles (CDRs), actin-based structures associated with increased cell motility. Here we show that mechanical changes in matrix stiffness enhance the formation of CDRs in VSMCs in response to PDGF stimulation. Our data indicate that matrix stiffness increases cellular contractility, and that intracellular pre-stress is necessary for robust CDR formation. When treated with agonists that promote contractility, cells increase CDR formation, whereas agonists that inhibit contractility lead to decreased CDR formation. Substrate stiffness promotes CDR formation in response to PDGF by upregulating Src activity through myosin light chain kinase. Together, these data indicate that vessel stiffening accompanying atherogenesis may exacerbate VSMC response to PDGF leading to CDR formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.