Evidence map›Paper›PMID 24348826›Full record

ArticleOncology letters2014

Interaction of a CD44+ head and neck squamous cell carcinoma cell line with a stromal cell-derived factor-1-expressing supportive niche: An

Anne Faber, Christoph Aderhold, Ulrich Reinhart Goessler, Karl Hoermann, Johannes David Schultz, Claudia Umbreit, Ute Walliczek, Jens Stern-Straeter

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Extracellular matrix and its therapeutic potential for cancer treatment.Signal transduction and targeted therapy · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anne FaberDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Christoph AderholdDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Ulrich Reinhart GoesslerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Karl HoermannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Johannes David SchultzDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Claudia UmbreitDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Ute WalliczekDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
Jens Stern-StraeterDepartment of Otorhinolaryngology, Head and Neck Surgery, University Medical Centre Mannheim, Mannheim D-68167, Germany.
University Medical Centre Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cancer stem cell (CSC) theory implies that CSCs are surrounded by supportive stromal cells, which are known as the CSC niche. Stromal cell-derived factor-1 (SDF-1) shows a multitude of functional effects in head and neck squamous cell carcinoma (HNSCC) cells, including migration and polarization. Therefore, the SDF-1-CXCR4 axis may be involved in the pathophysiology of the progression, recurrence and metastasis of malignant diseases of the head and neck. In the present study, the CD44

Indexed as

cancer stem cellsCXCR4head and neck squamous cell carcinomaSDF-1stem cell niche

Identifiers

PMID24348826
PMCPMC3861560
OpenAlexW2019030271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.