ArticleExperimental and therapeutic medicine2014
Apoptosis and p53 expression in the placental villi of females with unexplained recurrent spontaneous abortion.
Article in Experimental and therapeutic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between p53 polymorphism at codon 72 and recurrent spontaneous abortion.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Pooled it
- Association study ofTurkish journal of obstetrics and gynecology · 2025Article
- Antioxidant Defenses, Oxidative Stress Responses, and Apoptosis Modulation in Spontaneous Abortion: An Immunohistochemistry Analysis of First-Trimester Chorionic Villi.Life (Basel, Switzerland) · 2024Article
- Platelet-derived microparticles and their cargos: The past, present and future.Asian journal of pharmaceutical sciences · 2024Review
- Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis.Journal of nanobiotechnology · 2023Article
- The sequence variation of mitochondrial tRNA tyrosine and cysteine among Iranian women with idiopathic recurrent miscarriage: A case-control study.International journal of reproductive biomedicine · 2023Article
- Evaluation of the Effect of the Fibroblast Growth Factor Type 2 (FGF-2) Administration on Placental Gene Expression in a Murine Model of Preeclampsia Induced by L-NAME.International journal of molecular sciences · 2022Article
- Aberrant gene expression of superoxide dismutases in Chlamydia trachomatis-infected recurrent spontaneous aborters.Scientific reports · 2022Article
- Clinical Features and Risk Factors of Mortality in Patients with Posterior Reversible Encephalopathy Syndrome.Behavioural neurology · 2022Article
- The alteration and potential relationship of vaginal microbiota and chemokines for unexplained recurrent spontaneous abortion.Medicine · 2020Observational
- The role of FAS, FAS-L, BAX, and BCL-2 gene polymorphisms in determining susceptibility to unexplained recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2019Article
- Expression of galectin-3 and apoptosis in placental villi from patients with missed abortion during early pregnancy.Experimental and therapeutic medicine · 2019Article
- Disordered p53-MALAT1 pathway is associated with recurrent miscarriage.The Kaohsiung journal of medical sciences · 2019Article
- Androgen-induced alterations in endometrial proteins crucial in recurrent miscarriages.Oncotarget · 2018Article
- Placental apoptosis in recurrent miscarriage.The Kaohsiung journal of medical sciences · 2017Article
- The inhibiting effect of the transcription factor p53 on dengue virus infection by activating the type I interferon.Oncotarget · 2017Article
- Association of miR-34a-3p/5p, miR-141-3p/5p, and miR-24 in Decidual Natural Killer Cells with Unexplained Recurrent Spontaneous Abortion.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.PloS one · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to explore the level of apoptosis and p53 expression in the placental villi of patients with unexplained recurrent spontaneous abortion (URSA). Fifty-three pregnant females with URSA and 32 pregnant females who required an induced abortion were selected as the subjects of this study. Placental villus tissues were collected from June 2010 to June 2012 and quantitative polymerase chain reaction (qPCR) and immunohistochemical analysis were performed to determine the mRNA and protein levels of p53 in the placental villus tissues. The level of apoptosis in the tissues was studied using terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL) assay. The mRNA and protein expression levels of p53 in the URSA group were significantly higher than those in the control group (P<0.05). Furthermore, the levels of apoptosis were increased markedly in the URSA group compared with the control group (P<0.05). In conclusion, the placental villi of patients with URSA express a high level of p53, which may result in cell apoptosis and lead to recurrent spontaneous abortion.
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