ArticleComputational and mathematical methods in medicine2013
Modeling the chemoelectromechanical behavior of skeletal muscle using the parallel open-source software library OpenCMISS.
Article in Computational and mathematical methods in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- JiSuJi, a virtual muscle for small animal simulations, accurately predicts force from naturalistic spike trains.bioRxiv : the preprint server for biology · 2025Article
- Constitutive Models for Active Skeletal Muscle: Review, Comparison, and Application in a Novel Continuum Shoulder Model.International journal for numerical methods in biomedical engineering · 2025Review
- A chemo-mechanical constitutive model for muscle activation in bat wing skins.Journal of the Royal Society, Interface · 2024Article
- [Advances in digital twins technology of human skeletal muscle].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
- Integration of neural architecture within a finite element framework for improved neuromusculoskeletal modeling.Scientific reports · 2021Article
- Microstructural analysis of skeletal muscle force generation during aging.International journal for numerical methods in biomedical engineering · 2020Article
- Morphological Computation Increases From Lower- to Higher-Level of Biological Motor Control Hierarchy.Frontiers in robotics and AI · 2020Article
- Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model.Frontiers in physiology · 2019Article
- Speedup computation of HD-sEMG signals using a motor unit-specific electrical source model.Medical & biological engineering & computing · 2018Article
- Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems.Frontiers in physiology · 2018Article
- A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation.PLoS computational biology · 2017Article
- Multiscale musculoskeletal modelling, data-model fusion and electromyography-informed modelling.Interface focus · 2016Article
- The Role of Parvalbumin, Sarcoplasmatic Reticulum Calcium Pump Rate, Rates of Cross-Bridge Dynamics, and Ryanodine Receptor Calcium Current on Peripheral Muscle Fatigue: A Simulation Study.Computational and mathematical methods in medicine · 2016Article
- Predicting electromyographic signals under realistic conditions using a multiscale chemo-electro-mechanical finite element model.Interface focus · 2015Article
- Strategies for efficient numerical implementation of hybrid multi-scale agent-based models to describe biological systems.Cellular and molecular bioengineering · 2015Article
- Variational principles for buckling of microtubules modeled as nonlocal orthotropic shells.Computational and mathematical methods in medicine · 2014Article
- A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements.Frontiers in physiology · 2014Article
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Authors and funding
2 authors.
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Abstract
An extensible, flexible, multiscale, and multiphysics model for nonisometric skeletal muscle behavior is presented. The skeletal muscle chemoelectromechanical model is based on a bottom-up approach modeling the entire excitation-contraction pathway by strongly coupling a detailed biophysical model of a half-sarcomere to the propagation of action potentials along skeletal muscle fibers and linking cellular parameters to a transversely isotropic continuum-mechanical constitutive equation describing the overall mechanical behavior of skeletal muscle tissue. Since the multiscale model exhibits separable time scales, a special emphasis is placed on employing computationally efficient staggered solution schemes. Further, the implementation builds on the open-source software library OpenCMISS and uses state-of-the-art parallelization techniques taking advantage of the unique anatomical fiber architecture of skeletal muscles. OpenCMISS utilizes standardized data structures for geometrical aspects (FieldML) and cellular models (CellML). Both standards are designed to allow for a maximum flexibility, reproducibility, and extensibility. The results demonstrate the model's capability of simulating different aspects of nonisometric muscle contraction and efficiently simulating the chemoelectromechanical behavior in complex skeletal muscles such as the tibialis anterior muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.