ArticleEvidence-based complementary and alternative medicine : eCAM2013
Polysaccharides-Rich Extract of Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst Accelerates Wound Healing in Streptozotocin-Induced Diabetic Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.International journal of cosmetic science · 2026Article
- Integrative In Vivo and Proteomic Analysis of aMolecules (Basel, Switzerland) · 2026Article
- Study of the Cytotoxic and Wound Healing Activity of Polysaccharides fromMolecules (Basel, Switzerland) · 2026Article
- Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury.Frontiers in pharmacology · 2026Article
- Genome-wide CRISPR/Cas9 screening reveals lipid metabolism and inflammatory signalling as modulators of ganoderic acid DM cytotoxicity.Journal of genetics · 2026Article
- Unlocking the therapeutic potential of bioactive compounds in3 Biotech · 2025Review
- Effects of different doses of Ganoderic Acid A on nociceptive behaviour and inflammatory parameters in polyarthritic mice rheumatoid arthritis model.Scientific reports · 2025Article
- Diabetic Wound Healing: Factors, Mechanisms, and Treatment Strategies Using Herbal Components.Current drug targets · 2025Review
- Article
- A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.International journal of molecular sciences · 2024Article
- Topical Neuropeptide Y for Ischemic Skin Wounds.International journal of molecular sciences · 2024Article
- Use of Medicinal Plants in the Process of Wound Healing: A Literature Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Polysaccharide and ethanol extracts ofHeliyon · 2023Article
- Botanical Ingredient Forensics: Detection of Attempts to Deceive Commonly Used Analytical Methods for Authenticating Herbal Dietary and Food Ingredients and Supplements.Journal of natural products · 2023Review
- The Wound Healing Potential ofMycobiology · 2023Review
- Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides.Biological trace element research · 2022Review
- Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats.BioMed research international · 2022Article
- Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds.BioMed research international · 2022Review
- Skin Wound-Healing Potential of Polysaccharides from Medicinal MushroomJournal of fungi (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ganoderma lucidum (M.A. Curtis:Fr.) P. Karst is a popular medicinal mushroom. Scientific reports had shown that the wound healing effects of G. lucidum were partly attributed to its rich polysaccharides. However, little attention has been paid to its potential effects on wounds associated with diabetes mellitus. In this study, we evaluated the wound healing activity of the hot aqueous extract of G. lucidum in streptozotocin-induced diabetic rats. The extract of G. lucidum was standardised based on chemical contents (w/w) of total polysaccharides (25.1%), ganoderic acid A (0.45%), and adenosine (0.069%). Six groups of six rats were experimentally wounded in the posterior neck region. Intrasite gel was used as a positive control and aqueous cream as the placebo. Topical application with 10% (w/w) of mushroom extract-incorporated aqueous cream was more effective than that with Intrasite gel in terms of wound closure. The antioxidant activity in serum of rats treated with aqueous extract of G. lucidum was significantly higher; whereas the oxidative protein products and lipid damage were lower when compared to those of the controls. These findings strongly support the beneficial effects of standardised aqueous extract of G. lucidum in accelerating wound healing in streptozotocin-induced diabetic rats.
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Registered trials
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