ArticleEvidence-based complementary and alternative medicine : eCAM2013
Bioinformatics analysis for the antirheumatic effects of huang-lian-jie-du-tang from a network perspective.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Differential effects of Huang-Lian-Jie-Du Decoction on Alzheimer's disease and normal rats.Frontiers in pharmacology · 2025Article
- A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Article
- Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.Drug design, development and therapy · 2022Article
- Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the "brain-gut" axis through multiple integrated omics.Alzheimer's research & therapy · 2021Article
- Network pharmacological systems study of Huang-Lian-Tang in the treatment of glioblastoma multiforme.Oncology letters · 2021Article
- Effects of Huang-Lian-Jie-Du Decoction on Oxidative Stress and AMPK-SIRT1 Pathway in Alzheimer's Disease Rat.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective.Chinese journal of integrative medicine · 2020Review
- Traditional Oriental Medicines and Alzheimer's Disease.Aging and disease · 2019Review
- Network Pharmacology Analysis ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Huang-Lian-Jie-Du-Decoction Ameliorates Hyperglycemia and Insulin Resistant in Association With Gut Microbiota Modulation.Frontiers in microbiology · 2018Article
- The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs.Scientific reports · 2017Article
- A network-based method for mechanistic investigation of Shexiang Baoxin Pill's treatment of cardiovascular diseases.Scientific reports · 2017Article
- Pharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.PloS one · 2016Article
- Analysis of Cynandione A's Anti-Ischemic Stroke Effects from Pathways and Protein-Protein Interactome.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huang-Lian-Jie-Du-Tang (HLJDT) is a classic TCM formula to clear "heat" and "poison" that exhibits antirheumatic activity. Here we investigated the therapeutic mechanisms of HLJDT at protein network level using bioinformatics approach. It was found that HLJDT shares 5 target proteins with 3 types of anti-RA drugs, and several pathways in immune system and bone formation are significantly regulated by HLJDT's components, suggesting the therapeutic effect of HLJDT on RA. By defining an antirheumatic effect score to quantitatively measure the therapeutic effect, we found that the score of each HLJDT's component is very low, while the whole HLJDT achieves a much higher effect score, suggesting a synergistic effect of HLJDT achieved by its multiple components acting on multiple targets. At last, topological analysis on the RA-associated PPI network was conducted to illustrate key roles of HLJDT's target proteins on this network. Integrating our findings with TCM theory suggests that HLJDT targets on hub nodes and main pathway in the Hot ZENG network, and thus it could be applied as adjuvant treatment for Hot-ZENG-related RA. This study may facilitate our understanding of antirheumatic effect of HLJDT and it may suggest new approach for the study of TCM pharmacology.
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Registered trials
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