Evidence map›Paper›PMID 24348636›Full record

ReviewHepatitis monthly2013

The role of celiac disease in severity of liver disorders and effect of a gluten free diet on diseases improvement.

Mohammad Rostami-Nejad, Thea Haldane, David Aldulaimi, Seyed Moayed Alavian, Mohammad Reza Zali, Kamran Rostami

Abstract readReview
In one paragraph

Review in Hepatitis monthly, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Microscopic enteritis: Bucharest consensus.World journal of gastroenterology · 2015
    Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Gut-liver axis and disease infidelity: a subject worth exploring.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Rostami-NejadDepartment of Celiac Disease, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Thea HaldaneDepartment of Gastroenterology, Alexandra Hospital, Worcestershire, UK.
David AldulaimiDepartment of Gastroenterology, Alexandra Hospital, Worcestershire, UK.
Seyed Moayed AlavianBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran ; Middle East Liver Disease Center, Tehran, IR Iran.
Mohammad Reza ZaliDepartment of Celiac Disease, Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Kamran RostamiDepartment of Gastroenterology, Darent Valley Hospital, Darenth Wood Road, Dartford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextCeliac disease (CD) is defined as a permanent intolerance to ingested gluten. The intolerance to gluten results in immune-mediated damage of small intestine mucosa manifested by villous atrophy and crypt hyperplasia. These abnormalities resolve with initiationa gluten-free diet. EVIDENCE ACQUISITION: PubMed, Ovid, and Google were searched for full text articles published between 1963 and 2012. The associated keywords were used, and papers described particularly the impact of celiac disease on severity of liver disorder were identified.

resultsRecently evidence has emerged revealingthat celiac disease not only is associated with small intestine abnormalities and malabsorption, but is also a multisystem disorder affecting other systems outside gastrointestinal tract, including musculo-skeletal, cardiovascular and nervous systems. Some correlations have been assumed between celiac and liver diseases. In particular, celiac disease is associated with changes in liver biochemistry and linked to alter the prognosis of other disorders. This review will concentrate on the effect of celiac disease and gluten-free diets on the severity of liver disorders.

conclusionsAlthough GFD effect on the progression of CD associated liver diseases is not well defined, it seems that GFD improves liver function tests in patients with a hypertransaminasemia.

Indexed as

Celiac DiseaseLiver DiseaseSeverity

Identifiers

PMID24348636
PMCPMC3842525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.