ReviewInternational journal of endocrinology and metabolism2013
The role of estrogen in the treatment of men with schizophrenia.
Review in International journal of endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Raloxifene and progesterone neuroprotection in a female mouse model of Parkinson's disease.Frontiers in neuroscience · 2026Article
- Experiences in Accessing Treatment Among Females with Schizophrenia: A Qualitative Study from Turkey.Healthcare (Basel, Switzerland) · 2025Article
- Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders.Molecular biology reports · 2024Review
- Inflammatory markers of symptomatic remission at 6 months in patients with first-episode schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- The Hypothalamic-Pituitary-Gonadal Axis in Men with Schizophrenia.International journal of molecular sciences · 2023Review
- Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity.ACS omega · 2023Article
- Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment.Journal of molecular neuroscience : MN · 2021Article
- Gaps or links between hormonal therapy and schizophrenia? (Review).Experimental and therapeutic medicine · 2020Review
- Sex differences in schizophrenia, bipolar disorder, and post-traumatic stress disorder: Are gonadal hormones the link?British journal of pharmacology · 2019Review
- Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress in Schizophrenia.Molecular neuropsychiatry · 2019Article
- Women who suffer from schizophrenia: Critical issues.World journal of psychiatry · 2018Review
- Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior.Neuropharmacology · 2018Article
- SAP97 regulates behavior and expression of schizophrenia risk enriched gene sets in mouse hippocampus.PloS one · 2018Article
- Translational Significance of Selective Estrogen Receptor Modulators in Psychiatric Disorders.International journal of endocrinology · 2018Review
- L-Type Calcium Channels Modulation by Estradiol.Molecular neurobiology · 2017Review
- 17β-Estradiol-Induced Synaptic Rearrangements Are Accompanied by Altered Ectonucleotidase Activities in Male Rat Hippocampal Synaptosomes.Journal of molecular neuroscience : MN · 2017Article
- Estrogen Signaling as a Therapeutic Target in Neurodevelopmental Disorders.The Journal of pharmacology and experimental therapeutics · 2017Review
- Schizophrenia interactome with 504 novel protein-protein interactions.NPJ schizophrenia · 2016Article
- Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?Schizophrenia research and treatment · 2016Article
- ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a debilitating and pervasive mental illness with devastating effects on many aspects of psychological, cognitive and social wellbeing. Epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women, suggesting that estrogen plays a "protective" role . Adjunctive estrogen therapy has been shown to be effective in enhancing the treatment of schizophrenia in women. In men, consideration of estrogen therapy has been impacted by concerns of feminisation, however, clinical trials using estrogen to treat prostate cancer, bone density loss and even aggression in men with dementia or traumatic brain injury, show estrogen to be a safe and effective therapy. Findings do, however, suggest that further exploration of a therapeutic role for adjunctive estradiol treatment in men with schizophrenia is warranted. The development of the new estrogen compounds - Selective Estrogen Receptor Modulators (SERMs) which do not cause feminisation - opens up the possibility of using a different type of estrogen for a longer period of time at higher doses. Estrogen could therefore prove to be an important component in the treatment of psychotic symptoms in men with schizophrenia. This review explains the scientific rationale behind the estrogen hypothesis and how it can be clinically utilised to address concerns unique to the care of men with schizophrenia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.