ArticleGastroenterology research and practice2013
Dominant fecal microbiota in newly diagnosed untreated inflammatory bowel disease patients.
Article in Gastroenterology research and practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.United European gastroenterology journal · 2019Pooled it
- Trial
- Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses.Stem cell research & therapy · 2025Article
- Polystyrene Microplastics Can Aggravate the Damage of the Intestinal Microenvironment Caused by Okadaic Acid: A Prevalent Algal Toxin.Marine drugs · 2025Article
- Interrelationships of the Intestinal Microbiome, Trimethylamine N-Oxide and Lipopolysaccharide-Binding Protein with Crohn's Disease Activity.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Article
- Coronavirus Disease 2019 (COVID-19) Pandemic Lifestyle Changes May Have Influenced Small Bowel Microbial Composition and Microbial Resistance.Digestive diseases and sciences · 2023Article
- Effects of Softening Dry Food with Water on Stress Response, Intestinal Microbiome, and Metabolic Profile in Beagle Dogs.Metabolites · 2022Article
- Dietary ε-Polylysine Affects on Gut Microbiota and Plasma Metabolites Profiling in Mice.Frontiers in nutrition · 2022Article
- Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease.Microorganisms · 2021Review
- Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism.Frontiers in immunology · 2021Review
- Alterations of Gut Microbiota in Patients With Graves' Disease.Frontiers in cellular and infection microbiology · 2021Article
- Mini-Review: Human Microbiome and Rheumatic Diseases.Frontiers in cellular and infection microbiology · 2020Review
- Potential Vaccines for Treating Crohn's DiseaseIranian biomedical journal · 2020Review
- Temporal Dynamics of Chronic Inflammation on the Cecal Microbiota in IL-10Frontiers in immunology · 2020Article
- Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Effect of a multistrain probiotic (LactofloreneNeurobiology of stress · 2019Article
- Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.Clinical and experimental gastroenterology · 2019Article
- Determinants of IBD Heritability: Genes, Bugs, and More.Inflammatory bowel diseases · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge about the microbiota associated with the onset of IBD is limited. The aim of our study was to investigate the correlation between IBD and the fecal microbiota for early diagnosed untreated patients. The fecal samples used were a part of the Inflammatory Bowel South-Eastern Norway II (IBSEN II) study and were collected from CD patients (n = 30), UC patients (n = 33), unclassified IBD (IBDU) patients (n = 3), and from a control group (n = 34). The bacteria associated with the fecal samples were analyzed using a direct 16S rRNA gene-sequencing approach combined with a multivariate curve resolution (MCR) analysis. In addition, a 16S rRNA gene clone library was prepared for the construction of bacteria-specific gene-targeted single nucleotide primer extension (SNuPE) probes. The MCR analysis resulted in the recovery of five pure components of the dominant bacteria present: Escherichia/Shigella, Faecalibacterium, Bacteroides, and two components of unclassified Clostridiales. Escherichia/Shigella was found to be significantly increased in CD patients compared to control subjects, and Faecalibacterium was found to be significantly reduced in CD patients compared to both UC patients and control subjects. Furthermore, a SNuPE probe specific for Escherichia/Shigella showed a significant overrepresentation of Escherichia/Shigella in CD patients compared to control subjects. In conclusion, samples from CD patients exhibited an increase in Escherichia/Shigella and a decrease in Faecalibacterium indicating that the onset of the disease is associated with an increase in proinflammatory and a decrease in anti-inflammatory bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.