ArticleGastroenterology research and practice2013
Parenteral nutrition-induced cholestasis in neonates: where does the problem lie?
Article in Gastroenterology research and practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Sepsis profile among preterm infants with enterostomy and fecal transfer: a multicenter retrospective cohort study.Molecular and cellular pediatrics · 2026Article
- Flow efficiency of 3D-printed refeeding tubes in a simulated neonatal high-output stoma model.Pediatric surgery international · 2026Article
- Neurodevelopment Outcomes in Very-Low-Birth-Weight Infants with Metabolic Bone Disease at 2 Years of Age.Children (Basel, Switzerland) · 2024Article
- Pathogenic Novel Heterozygous Variant c.1076c>T p. (Ser359Phe) chr1: 120512166 in NOTCH2 Gene, Type 2 Alagille Syndrome Causing Neonatal Cholestasis: A Case Report.The American journal of case reports · 2022Article
- Extremely low gestational age infants: Developing a multidisciplinary care bundle.Paediatrics & child health · 2021Article
- Thrombin Generation in Preterm Newborns With Intestinal Failure-Associated Liver Disease.Frontiers in pediatrics · 2020Article
- Nutritional Support of Very Low Birth Weight Infants in a Tertiary Center in a Developing Country.Journal of clinical medicine research · 2019Article
- Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis.Italian journal of pediatrics · 2018Article
- Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience.Pediatric gastroenterology, hepatology & nutrition · 2016Article
- The Effect of Fish Oil-Based Lipid Emulsion and Soybean Oil-Based Lipid Emulsion on Cholestasis Associated with Long-Term Parenteral Nutrition in Premature Infants.Gastroenterology research and practice · 2016Article
- Intestinal Microbiota, Lipids, and the Pathogenesis of Intestinal Failure-Associated Liver Disease.The Journal of pediatrics · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Parenteral nutrition (PN) is an effective method of nourishing the neonate who is unable to receive full enteral feeds. Cholestasis can be a complication of PN and can lead to severe liver damage. Aim. We describe our patient population and determine risk factors for developing PN cholestasis. Methods. Retrospective chart review of newborns admitted from January 2006 to May 2011 to the Neonatal Intensive Care Unit at our institution and received PN >14 days. Cholestasis was defined as serum conjugated bilirubin >50 μ mol/L. Results. Eighty-seven newborns were included; 18 (20.7%) developed PN cholestasis. The most frequent surgical condition for both groups was gastroschisis (8/87; 9.2%). No significant differences were found between the cholestasis and control groups for the following parameters: birth weight, gestational age, intrauterine growth restriction, Apgar scores, and day of life at initiation of enteral feeds. Duration of PN in days and dosage of carbohydrates in g/kg/day were significantly higher in the cholestasis group than the control group. Conclusion. PN-related cholestasis presented in one-fifth of neonates receiving PN for more than two weeks. Longer duration of PN and higher dosage of carbohydrates were independent risk factors for the development of PN cholestasis in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.