ReviewFrontiers in immunology2013
The gastrointestinal frontier: IgA and viruses.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI.4 and GII.4 VLPs without adjuvant.Frontiers in immunology · 2023Trial
- Probiotic stool secretory immunoglobulin A modulation in children with gastroenteritis: a randomized clinical trial.The American journal of clinical nutrition · 2021Trial
- IgA is necessary and sufficient to prevent norovirus infection in mice.Science translational medicine · 2026Article
- The Effect of Food Processing and Preservation on the Survivability of Group A Rotavirus (SA11) in Simulated and Real Food Models.Food and environmental virology · 2026Article
- Review
- Variation of rabbit serum IgA in relation to RHDV vaccination and infection: implications for serological diagnosis and epidemiological investigations.Veterinary research · 2026Article
- Mechanisms of Norovirus Immunity: Implications for Vaccine Design.Annual review of pathology · 2026Review
- Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models.Open forum infectious diseases · 2025Article
- Gastrointestinal germinal center B cell depletion and reduction in IgAScience immunology · 2024Article
- Epidemiology of group A rotavirus in children under five years of age with gastroenteritis in N'Djamena, Chad.BMC infectious diseases · 2024Article
- Review
- Gut bacteria induce IgA expression in pituitary hormone-secreting cells during aging.iScience · 2023Article
- Evolutive emergence and divergence of an Ig regulatory node: An environmental sensor getting cues from the aryl hydrocarbon receptor?Frontiers in immunology · 2023Review
- Bowel ischemia as onset of COVID-19 in otherwise asymptomatic patients with persistently negative swab.Journal of internal medicine · 2022Article
- The role of goblet cells in viral pathogenesis.The FEBS journal · 2021Review
- Gut Microbiota, Microbial Metabolites and Human Physical Performance.Metabolites · 2021Review
- Know your enemy or find your friend?-Induction of IgA at mucosal surfaces.Immunological reviews · 2021Review
- Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.Cell host & microbe · 2021Article
- Immune Evaluation of RecombinantFrontiers in immunology · 2021Article
- Antibody Class(es) Predictor for Epitopes (AbCPE): A Multi-Label Classification Algorithm.Frontiers in bioinformatics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral gastroenteritis is one of the leading causes of diseases that kill ~2.2 million people worldwide each year. IgA is one of the major immune effector products present in the gastrointestinal tract yet its importance in protection against gastrointestinal viral infections has been difficult to prove. In part this has been due to a lack of small and large animal models in which pathogenesis of and immunity to gastrointestinal viral infections is similar to that in humans. Much of what we have learned about the role of IgA in the intestinal immune response has been obtained from experimental animal models of rotavirus infection. Rotavirus-specific intestinal IgA appears to be one of the principle effectors of long term protection against rotavirus infection. Thus, there has been a focus on understanding the immunological pathways through which this virus-specific IgA is induced during infection. In addition, the experimental animal models of rotavirus infection provide excellent systems in which new areas of research on viral-specific intestinal IgA including the long term maintenance of viral-specific IgA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.