ReviewFrontiers in human neuroscience2013
Facets and mechanisms of adaptive pain behavior: predictive regulation and action.
Review in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- ALE meta-analysis reveals dissociable networks for affective and discriminative aspects of touch.Human brain mapping · 2016Pooled it
- Behavioral responses to noxious stimuli shape the perception of pain.Scientific reports · 2017Trial
- Controllability changes pain perception by increasing the precision of expectations.Nature communications · 2025Article
- Hypercapnia Reduces Perceived Heat Pain in Healthy Subjects.European journal of pain (London, England) · 2025Article
- Psychosocial Outcomes of Pain and Pain Management in Adults with Osteogenesis Imperfecta: A Qualitative Study.Journal of clinical psychology in medical settings · 2024Article
- Modulation of multisensory nociceptive neurons in monkey cortical area 7b and behavioral correlates.Journal of neurophysiology · 2024Article
- Cognitive exertion affects the appraisal of one's own and other people's pain.Scientific reports · 2023Article
- Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions.Cells · 2023Review
- Prediction and action in cortical pain processing.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Role of the Skin in Interoception: A Neglected Organ?Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- Osteopathic Care as (En)active Inference: A Theoretical Framework for Developing an Integrative Hypothesis in Osteopathy.Frontiers in psychology · 2022Article
- Analgesic Efficacy and Safety of Local Infiltration Following Lumbar Decompression Surgery: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2021Review
- Synthesis and Pharmacological Evaluation of Novel 2,3,4,5-tetrahydro[1,3]diazepino[1,2-Molecules (Basel, Switzerland) · 2021Article
- Predictive coding models for pain perception.Journal of computational neuroscience · 2021Article
- Mutation Carriers with Reduced C-Afferent Density Reveal Cortical Dynamics of Pain-Action Relationship during Acute Pain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life.Pain research & management · 2020Article
- The neuroscience of vision and pain: evolution of two disciplines.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- The Role of Sensorimotor Processes in Pain Empathy.Brain topography · 2019Review
- Sensory-specific predictive models in the human anterior insula.F1000Research · 2019Article
- Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural mechanisms underlying nociception and pain perception are considered to serve the ultimate goal of limiting tissue damage. However, since pain usually occurs in complex environments and situations that call for elaborate control over behavior, simple avoidance is insufficient to explain a range of mammalian pain responses, especially in the presence of competing goals. In this integrative review we propose a Predictive Regulation and Action (PRA) model of acute pain processing. It emphasizes evidence that the nervous system is organized to anticipate potential pain and to adjust behavior before the risk of tissue damage becomes critical. Regulatory processes occur on many levels, and can be dynamically influenced by local interactions or by modulation from other brain areas in the network. The PRA model centers on neural substrates supporting the predictive nature of pain processing, as well as on finely-calibrated yet versatile regulatory processes that ultimately affect behavior. We outline several operational categories of pain behavior, from spinally-mediated reflexes to adaptive voluntary action, situated at various neural levels. An implication is that neural processes that track potential tissue damage in terms of behavioral consequences are an integral part of pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.