ArticleFrontiers in behavioral neuroscience2013
GluN2B-containing NMDA receptors and AMPA receptors in medial prefrontal cortex are necessary for odor span in rats.
Article in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Olfactory Dysfunction in Schizophrenia: Evaluating Olfactory Abilities Across Species.Current topics in behavioral neurosciences · 2023Review
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Roles of the medial prefrontal cortex, mediodorsal thalamus, and their combined circuit for performance of the odor span task in rats: analysis of memory capacity and foraging behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Effects of NMDA antagonist dizocilpine (MK-801) are modulated by the number of distractor stimuli in the rodent odor span task of working memory.Neurobiology of learning and memory · 2019Article
- Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats.Experimental and clinical psychopharmacology · 2018Article
- Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine.Neurobiology of learning and memory · 2017Article
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Validation of the human odor span task: effects of nicotine.Psychopharmacology · 2017Article
- Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: role of NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Olfactory Stimulus Control and the Behavioral Pharmacology of Remembering.Behavior analysis (Washington, D.C.) · 2016Article
- Behavioral pharmacology of the odor span task: Effects of flunitrazepam, ketamine, methamphetamine and methylphenidate.Journal of the experimental analysis of behavior · 2016Article
- Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Cortical GluN2B deletion attenuates punished suppression of food reward-seeking.Psychopharmacology · 2015Article
- Conditional loss of GluN2B in cortex and hippocampus impairs attentional set formation.Behavioral neuroscience · 2015Article
- Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.Genes, brain, and behavior · 2015Review
- Article
- Evidence for novelty reward cross-cueing in the odor span task in rats: implications for odor-based reward-motivated tasks.Learning & memory (Cold Spring Harbor, N.Y.)Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Working memory is a type of short-term memory involved in the maintenance and manipulation of information essential for complex cognition. While memory span capacity has been extensively studied in humans as a measure of working memory, it has received considerably less attention in rodents. Our aim was to examine the role of the N-methyl-D-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors in odor span capacity using systemic injections or infusions of receptor antagonists into the medial prefrontal cortex (mPFC). Long Evans rats were trained on a well-characterized odor span task (OST). Initially, rats were trained to dig for a food reward in sand followed by training on a non-match to sample discrimination using sand scented with household spices. The rats were then required to perform a serial delayed non-match to sample procedure which was their odor span. Systemic injection of the broad spectrum NMDA receptor antagonist 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) (10 mg/kg) or the GluN2B-selective antagonist Ro 25-6981 (10 mg/kg but not 6 mg/kg) significantly reduced odor span capacity. Infusions of the GluN2B- selective antagonist Ro 25-6981 (2.5 μg/hemisphere) into mPFC reduced span capacity, an effect that was nearly significant (p = 0.069). Infusions of the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (1.25 μg/hemisphere) into mPFC reduced span capacity and latency for the rats to make a choice in the task. These results demonstrate span capacity in rats depends on ionotropic glutamate receptor activation in the mPFC. Further understanding of the circuitry underlying span capacity may aid in the novel therapeutic drug development for persons with working memory impairments as a result of disorders such as schizophrenia and Alzheimer's disease.
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