ArticleSaudi journal of anaesthesia2013
Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries.
Article in Saudi journal of anaesthesia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04689945 (Metabolomic Profiling of Erector Spinae Plane Block for Breast Cancer Surgery), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolomic Profiling of Erector Spinae Plane Block for Breast Cancer Surgery
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Regional anesthesia might reduce recurrence and metastasis rates in adult patients with cancers after surgery: a meta-analysis.BMC anesthesiology · 2024Pooled it
- Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery.The Cochrane database of systematic reviews · 2021Pooled it
- Transversus abdominis plane block with general anesthesia blunts the perioperative stress response in patients undergoing radical gastrectomy.BMC anesthesiology · 2019Trial
- The impact of paravertebral nerve blockade on postoperative surgical site wound pain management in patients undergoing video-assisted thoracoscopic surgery for pulmonary carcinoma resection.International wound journal · 2024Article
- Trial watch: local anesthetics in cancer therapy.Oncoimmunology · 2024Article
- Review
- Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer.Frontiers in oncology · 2021Review
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- The efficacy of paravertebral block evaluated by pain-related biomarkers and reactive oxygen species (ROS) following surgery for breast cancer: A randomized controlled study.Saudi journal of anaesthesiaArticle
- In response to: Comparison of paravertebral and interpleural block in patients undergoing modified radical mastectomy.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextCytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery.
aimWe tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surgeries for cancer breast. SETTINGS AND
designControlled randomized study.
methodsForty cancer breast patients were divided in two groups; Group I received PVB and Group II received GA during performance of unilateral breast surgery without axillary clearance. Plasma concentrations of interleukin (IL)-6, IL-10, IL-12 and interferon-γ (IFN-γ) were measured and IL-10/IFN-γ were estimated in the following points; before starting PVB in Group I or induction of GA in Group II (Sample A), before skin incision (Sample B), at the end of procedure before shifting out of operating room (Sample C), 4-h post-operatively (Sample D) and 24-h post-operatively (Sample E). STATISTICAL ANALYSIS: unpaired Student t-test.
resultsIL-6 increased progressively in both groups with statistically significant lower levels in samples C and D in Group I. IL-10 levels showed progressive increasing in both groups without differences between groups. IL-12 showed progressive decrease in both groups with statistically significant higher levels in samples C and D in Group I. IFN-levels showed significantly higher levels in samples C and D in Group I. IL-10/IFN-γ ratio was significantly lower in Group II in samples C and D.
conclusionReplacing GA with PVB can attenuate cytokines response to cancer breast surgeries.
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Registered trials
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