ArticlePLoS genetics2013
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Maintenance of neuronal identity in C. elegans and beyond: Lessons from transcription and chromatin factors.Seminars in cell & developmental biology · 2024Review
- Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation.Cell reports · 2023Article
- Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance.Nature reviews. Molecular cell biology · 2022Review
- Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity.Genome research · 2022Article
- Nervous system-wide analysis of Hox regulation of terminal neuronal fate specification in Caenorhabditis elegans.PLoS genetics · 2022Article
- UsingFrontiers in pharmacology · 2022Review
- Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity iniScience · 2020Article
- The Conserved ASCL1/MASH-1 Ortholog HLH-3 Specifies Sex-Specific Ventral Cord Motor Neuron Fate inG3 (Bethesda, Md.) · 2020Article
- Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate inFrontiers in cell and developmental biology · 2020Review
- Distinct functions and temporal regulation of methylated histone H3 during early embryogenesis.Development (Cambridge, England) · 2019Article
- Characterization of paralogousGene: X · 2019Article
- Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality inGenetics · 2018Article
- High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model.ACS chemical neuroscience · 2018Article
- Repressive Chromatin inGenetics · 2018Review
- Distinct effects of tubulin isotype mutations on neurite growth inMolecular biology of the cell · 2017Article
- Article
- Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.Neuron · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although epigenetic control of stem cell fate choice is well established, little is known about epigenetic regulation of terminal neuronal differentiation. We found that some differences among the subtypes of Caenorhabditis elegans VC neurons, particularly the expression of the transcription factor gene unc-4, require histone modification, most likely H3K9 methylation. An EGF signal from the vulva alleviated the epigenetic repression of unc-4 in vulval VC neurons but not the more distant nonvulval VC cells, which kept unc-4 silenced. Loss of the H3K9 methyltransferase MET-2 or H3K9me2/3 binding proteins HPL-2 and LIN-61 or a novel chromodomain protein CEC-3 caused ectopic unc-4 expression in all VC neurons. Downstream of the EGF signaling in vulval VC neurons, the transcription factor LIN-11 and histone demethylases removed the suppressive histone marks and derepressed unc-4. Behaviorally, expression of UNC-4 in all the VC neurons caused an imbalance in the egg-laying circuit. Thus, epigenetic mechanisms help establish subtype-specific gene expression, which are needed for optimal activity of a neural circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.